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논문 기본 정보

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저자정보
Na Byeong-Gon (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Hwang Shin (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Ahn Chul-Soo (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Kim Ki-Hun (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Moon Deok-Bog (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Ha Tae-Yong (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Song Gi-Won (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Jung Dong-Hwan (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Park Gil-Chun (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Yoon Young-In (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Kang Woo-Hyoung (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Cho Hwui-Dong (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Kim Sang Hoon (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Hong Seung-Mo (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Lee Sung-Gyu (Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea)
저널정보
대한이식학회 Clinical Transplantation and Research Korean Journal of Transplantation Vol.35 No.1
발행연도
2021.1
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15 - 23 (9page)

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Background: Epithelioid hemangioendothelioma (EHE) is a rare borderline vascular tumor. Due to its rarity and protean behavior, the optimal treatment of hepatic EHE has not yet been standardized. This single-center study describes outcomes in patients with hepatic EHE who underwent living donor liver transplantation (LDLT). Methods: The medical records of patients who underwent LDLT for hepatic EHE from 2007 to 2016 were reviewed. Results: During 10-year period, four patients, one man and three women, of mean age 41.3±11.1 years, underwent LDLT for hepatic EHE. Based on imaging modalities, these patients were preoperatively diagnosed with EHE or hepatocellular carcinoma, with percutaneous liver biopsy confirming that all four had hepatic EHE. The tumors were multiple and scattered over entire liver, precluding liver resection. Blood tumor markers were not elevated, except that CA19-9 and des-γ-carboxy prothrombin was slightly elevated in one patient. Mean model for end-stage liver disease score was 10.8±5.7. All patients underwent LDLT using modified right liver grafts, with graft-recipient weight ratio of 1.11±0.19, and all recovered uneventfully after LDLT. One patient died due to tumor recurrence at 9 months, whereas the other three have done well without tumor recurrence, resulting in 5-year disease-free and overall patient survival rates of 75% each. The patient with tumor recurrence was classified as a high-risk patient based on the original and modified hepatic EHE-LT scoring systems. Conclusions: LDLT can be an effective treatment for patients with unresectable hepatic EHEs that are confined within the liver and absence of macrovascular invasion and lymph node metastasis.
#Borderline tumor #Recurrence #Vascular tumor #Metastasis #Immunohistochemical stain

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참고문헌 (30)

참고문헌 신청
Sardaro A / 2014 / Epithelioid hemangioendothelioma : an overview and update on a rare vascular tumor / Oncol Rev 8:259 google schola Fletcher CD / 2002 / World Health Organization classification of tumours: pathology and genetics of tumours of soft tissue and bone / IRAC Press google schola Ishak KG / 1984 / Epithelioid hemangioendothelioma of the liver : a clinicopathologic and follow-up study of 32 cases / Hum Pathol 15:839~852 google schola Lau K / 2011 / Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement : insights from an internet registry in the study of a rare cancer / Chest 140:1312~1318 google schola Mehrabi A / 2006 / Primary malignant hepatic epithelioid hemangioendothelioma : a comprehensive review of the literature with emphasis on the surgical therapy / Cancer 107:2108~2121 google schola

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