메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Lee Seohee (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Kim Jong Man (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Kim Sangjin (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Rhu Jinsoo (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Choi Gyu Seong (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea) Joh Jae-Won (Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea)
저널정보
대한이식학회 Clinical Transplantation and Research Korean Journal of Transplantation Vol.35 No.1
발행연도
2021.1
수록면
8 - 14 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Tacrolimus (TAC) is a main therapy for liver transplantation (LT) patients, but it has side effects such as chronic nephrotoxicity that progressively aggravate renal function. The purpose of this study was to retrospectively compare the renal function between a TAC group and a combination of everolimus and reduced TAC (EVR-TAC) group after deceased donor liver transplantation (DDLT). Methods: The study comprised 131 patients who underwent DDLT between January 2013 and April 2018 at our institution. They received TAC or EVR-TAC after DDLT. Everolimus (EVR) was introduced between 1 and 6 months after DDLT. Results: Thirty-six of 131 patients (27.5%) received EVR-TAC. The incidence of chronic kidney disease (CKD; estimated glomerular filtration rate, <60 mL/1.73 m2) in the EVR-TAC group was higher than in the TAC group (25% vs. 8.4%; P=0.019). Increasing serum creatinine (n=23, 63.9%) was the most common cause for adding EVR to treatment of the posttransplant patients. There were no statistical differences in acute rejection and CKD between the two groups. The TAC trough level was significantly lower in the EVR-TAC group than in the TAC group, and the renal function of the EVR-TAC group was worse than that of the TAC group until 1 year after DDLT. However, the renal function of the EVR-TAC group improved and became similar to that of TAC group at 3 years posttransplant. Conclusions: The present study suggests that EVR should be introduced as soon as possible after DDLT to reduce exposure to high doses of TAC to improve the renal function.
#Renal insufficiency #Immunosuppression #Calcineurin inhibitors

목차

등록된 정보가 없습니다.

참고문헌 (24)

참고문헌 신청
Brunet M / 2019 / Therapeutic drug monitoring of tacrolimus-personalized therapy : second consensus report / Ther Drug Monit 41:261~307 google schola Ojo AO / 2003 / Chronic renal failure after transplantation of a nonrenal organ / N Engl J Med 349:931~940 google schola Saliba F / 2018 / Association between renal dysfunction and major adverse cardiac events after liver transplantation : evidence from an international randomized trial of everolimus-based immunosuppression / Ann Transplant 23:751~757 google schola Saliba F / 2013 / Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study / Am J Transplant 13:1734~1745 google schola Fischer L / 2015 / Three-year outcomes in de novo liver transplant patients receiving everolimus with reduced tacrolimus: follow-up results from a randomized, multicenter study / Transplantation 99:1455~1462 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0