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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 146 - 152 (7page)
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초록· 키워드
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Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinuria after successful pancreas transplantation alone without evidence of calcineurin inhibitor (CNI) toxicity. A 22-year-old female patient with type I diabetes mellitus underwent pancreas transplantation alone. The patient already had retinopathy and mild proteinuria, which in this case, may mean diabetic nephropathy. Her glucose levels were managed within the normal range after successful pancreas transplantation. However, the amount of proteinuria fluctuated. Kidney needle biopsy was performed owing to severe elevation of proteinuria, 2 years after the transplantation. Electron microscopy revealed diabetic glomerulosclerosis without evidence of CNI toxicity. This case indicates that diabetic nephropathy can be aggravated after pancreas transplantation, despite well-managed glucose levels and absence of CNI toxicity.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Dean PG / 2017 / Pancreas transplantation / BMJ 357:j1321
Wisel SA / 2016 / Current outcomes in islet versus solid organ pancreas transplant for β-cell replacement in type 1 diabetes / Curr Opin Organ Transplant 21:399~404
Bekiari E / 2018 / Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis / BMJ 361:k1310
Redfield RR / 2016 / Pancreas transplantation in the modern era / Gastroenterol Clin North Am 45:145~166
Shin S / 2018 / Long-term effects of pancreas transplant alone on nephropathy in type 1 diabetic patients with optimal renal function / PLoS One 13:e0191421
Wisel SA / 2016 / Current outcomes in islet versus solid organ pancreas transplant for β-cell replacement in type 1 diabetes / Curr Opin Organ Transplant 21:399~404
Bekiari E / 2018 / Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis / BMJ 361:k1310
Redfield RR / 2016 / Pancreas transplantation in the modern era / Gastroenterol Clin North Am 45:145~166
Shin S / 2018 / Long-term effects of pancreas transplant alone on nephropathy in type 1 diabetic patients with optimal renal function / PLoS One 13:e0191421
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