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자료유형
학술저널
저자정보
Yun Kyung Cho (Seoul National University Bundang Hospital) So Yeon Hong (Seoul National University Bundang Hospital) Su Jeoung Jeon (Seoul National University Bundang Hospital) Hyung Wook Namgung (Seoul National University Bundang Hospital) Eunsook Lee (Seoul National University Bundang Hospital) Euni Lee (Seoul National University) Soo-Mee Bang (Seoul National University Bundang Hospital)
저널정보
대한혈액학회 Blood Research Blood Research Vol.54 No.1
발행연도
2019.1
수록면
23 - 30 (8page)

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BackgroundHematopoietic stem cell transplantation (HSCT) patients need parenteral nutrition be-cause of nausea, vomiting, and mucositis caused by conditioning regimens. The demand for glutamine increases during the HSCT period. We evaluated the effects of gluta-mine-containing parenteral nutrition on the clinical outcomes of HSCT patients.MethodsIn this retrospective analysis, we reviewed HSCT patients from Seoul National University from August 2013 to July 2017. Depending on their glutamine supplementation status, 91 patients were divided into 2 groups: glutamine group (N=44) and non-glutamine group (N=47). We analyzed the rate of weight change, infection (clinically/micro-biologically documented), complications (duration of mucositis and neutropenia, acute graft versus host disease), and 100-days mortality in each group.ResultsRegarding the clinical characteristics of the patients, there were no significant differences between the 2 groups except that there was a larger proportion of myeloablative con-ditioning regimen in the glutamine group (P=0.005). In the glutamine group, the average number of days of glutamine use, parenteral nutrition, and mucositis was 7.6±1.4,14.6±9.9, and 13.3±9.5, respectively. Furthermore, multivariate analysis revealed odds ratios of 0.37 (95% CI, 0.14‒0.96; P=0.042) and 0.08 (95% CI, 0.01‒0.98; P=0.048) for clinically documented infection and 100-days mortality, respectively, in the glutamine group.ConclusionResults showed that the glutamine group had less clinically documented infection and 100-days mortality than the non-glutamine group, but the other outcomes did not show significant differences. The extended duration of glutamine supplementation according to the period of total parenteral nutrition and mucositis should be considered.

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