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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 172 - 179 (8page)
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초록· 키워드
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Background: Glomerulonephritis is often treated with kidney-saving, but potentially diabetogenic immunosuppressants such as glucocorticosteroids and calcineurin inhibitors. Unfortunately, there are little data on dysglycemia before and after diagnosis and during treatment of glomerulonephritis. We aimed to evaluate the occurrence and risk factors for pre-diabetes and incident diabetes among non-diabetic patients with glomerular disease with or without treatment with immunosuppressants. Methods: A single-center, retrospective cohort study was performed on 229 non-diabetic immunosuppressantnaïve adults diagnosed with glomerulonephritis and renal vasculitis. Patients with known diabetes and prior immunosuppressant treatment were excluded. Outcomes of new-onset pre-diabetes and new-onset diabetes were defined according to American Diabetic Association criteria. Results: Pre-diabetes was present pre-biopsy in 74 of the 229 patients (32.3%). During the median follow-up of 34.0 (23.3-47.5) months, 29 patients (12.7%) developed new-onset diabetes and 58 (25.3%) had new-onset prediabetes. Immunosuppressive therapy in patients with pre-existing pre-diabetes was associated with increased odds of new-onset diabetes compared to those without either risk factor (26.0% versus 5.0%; odds ratio, 6.67; 95% confidence interval [CI], 1.41 to 31.64), P = 0.02). Conclusion: New-onset diabetes after immunosuppressant treatment occurred in one-quarter of patients with glomerulonephritis and pre-existing pre-diabetes. Physicians should screen for pre-diabetes when planning treatment with immunosuppressants, as its presence significantly increases the risk of diabetes mellitus.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Lim CC / 2018 / Long-term renal outcomes in multi-ethnic Southeast Asians with lupus nephritis : a retrospective cohort study / Intern Med J 48:1117~1123
Haynes R / 2014 / Evaluating the contribution of the cause of kidney disease to prognosis in CKD: results from the Study of Heart and Renal Protection (SHARP) / Am J Kidney Dis 64:40~48
Wakai K / 2004 / Trends in incidence of end-stage renal disease in Japan, 1983-2000 : age-adjusted and age-specific rates by gender and cause / Nephrol Dial Transplant 19:2044~2052
Salonen T / 2003 / Cost analysis of renal replacement therapies in Finland / Am J Kidney Dis 42:1228~1238
Lim CC / 2015 / Chronic kidney disease, cardiovascular disease and mortality : a prospective cohort study in a multi-ethnic Asian population / Eur J Prev Cardiol 22:1018~1026
Haynes R / 2014 / Evaluating the contribution of the cause of kidney disease to prognosis in CKD: results from the Study of Heart and Renal Protection (SHARP) / Am J Kidney Dis 64:40~48
Wakai K / 2004 / Trends in incidence of end-stage renal disease in Japan, 1983-2000 : age-adjusted and age-specific rates by gender and cause / Nephrol Dial Transplant 19:2044~2052
Salonen T / 2003 / Cost analysis of renal replacement therapies in Finland / Am J Kidney Dis 42:1228~1238
Lim CC / 2015 / Chronic kidney disease, cardiovascular disease and mortality : a prospective cohort study in a multi-ethnic Asian population / Eur J Prev Cardiol 22:1018~1026
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