지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 405 - 410 (6page)
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초록· 키워드
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Purpose: Whether active surveillance (AS) can be safely extended to patients with Gleason score (GS) 3+4 prostate cancer is highly debated. We examined the incidence and predictors of upgrading among patients with GS 3+4 disease. Materials and Methods: The study involved 377 patients with biopsy GS 3+4 who underwent robot-assisted laparoscopic radical prostatectomy (RP) from 2014 to 2018 at a single institution. We analyzed the rate of GS upgrading and used logistic regression to determine the predictors of upgrading. Results: A total of 168 (44.6%) patients with GS 3+4 experienced an upgrade in GS. In multivariable analysis, advanced age, prostate-specific antigen (PSA) level, PSA density (PSAD) and Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2) score were significant predictors of GS upgrading. When structured into a predictive model that included age ≥65 years, PSA ≥7.7 ng/mL, PSAD ≥0.475 ng/mL2 and PI-RADS v2 score 4–5, the probability of GS upgrading ranged from 36.4% to 65.7% when one to four of these factors were included. Conclusions: A substantial proportion of patients with GS 3+4 prostate cancer were upgraded after RP. However, according to our model combining clinical and imaging predictors, patients with a low risk of GS upgrading may be eligible candidates for AS.
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참고문헌 (29)
참고문헌 신청
Siegel RL / 2019 / Cancer statistics, 2019 / CA Cancer J Clin 69:7~34
Dahabreh IJ / 2012 / Active surveillance in men with localized prostate cancer : a systematic review / Ann Intern Med 156:582~590
Raldow AC / 2015 / Risk group and death from prostate cancer : implications for active surveillance in men with favorable intermediate-risk prostate cancer / JAMA Oncol 1:334~340
Cooperberg MR / 2011 / Outcomes of active surveillance for men with intermediate-risk prostate cancer / J Clin Oncol 29:228~234
Hamdy FC / 2016 / 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer / N Engl J Med 375:1415~1424
Dahabreh IJ / 2012 / Active surveillance in men with localized prostate cancer : a systematic review / Ann Intern Med 156:582~590
Raldow AC / 2015 / Risk group and death from prostate cancer : implications for active surveillance in men with favorable intermediate-risk prostate cancer / JAMA Oncol 1:334~340
Cooperberg MR / 2011 / Outcomes of active surveillance for men with intermediate-risk prostate cancer / J Clin Oncol 29:228~234
Hamdy FC / 2016 / 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer / N Engl J Med 375:1415~1424
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