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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 169 - 175 (7page)
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Purpose: Imaging studies can show metastasis in testicular cancer (TCa); however, a test for risk of metastasis in TCa has not been described. The ratio of aspartate aminotransferase to alanine aminotransferase, also called the De Ritis ratio (DRR), is used for many other malignancies. We aimed to evaluate the association between preoperatively assessed DRR and prognosis in patients with TCa. Materials and Methods: One hundred twenty-eight patients with TCa were enrolled in a retrospective study between March 2007 and January 2017. Clinical, biochemical, and pathological data were recorded. Univariate and multivariate logistic regression analyses were used. The prognostic value of DRR and the threshold value were assessed by use of receiver operating characteristic curves. Significance was defined as p<0.05. Results: Mean follow-up was 37±9.7 months. There were 45 and 73 TCa patients with and without lymph node metastasis, respectively. Lung metastases and other solid organ metastases occurred in 14 and 4 patients, respectively. The optimal DRR threshold was 1.30 for both retroperitoneal lymph node involvement and metastasis. DRR was determined as an independent prognostic factor for retroperitoneal lymph node involvement and organ metastasis in univariate and multivariate analyses (p<0.001, p=0.006 and p=0.002, p=0.047, respectively). Conclusions: A preoperative DRR greater than 1.30 may be an independent risk factor for retroperitoneal lymph node involvement and organ metastases in patients with TCa.
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참고문헌 (30)
참고문헌 신청
La Vecchia C / 2010 / Cancer mortality in Europe, 2000-2004, and an overview of trends since 1975 / Ann Oncol 21:1323~1360
Osbun N / 2017 / Characteristics of patients with sertoli and leydig cell testis neoplasms from a national population-based registry / Clin Genitourin Cancer 15:e263~e266
Jemal A / 2009 / Cancer statistics, 2009 / CA Cancer J Clin 59:225~249
Nigam M / 2015 / Increasing incidence of testicular cancer in the United States and Europe between 1992 and 2009 / World J Urol 33:623~631
Germà-Lluch JR / 2002 / Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish Germ-Cell Cancer Group (GG) / Eur Urol 42:553~562
Osbun N / 2017 / Characteristics of patients with sertoli and leydig cell testis neoplasms from a national population-based registry / Clin Genitourin Cancer 15:e263~e266
Jemal A / 2009 / Cancer statistics, 2009 / CA Cancer J Clin 59:225~249
Nigam M / 2015 / Increasing incidence of testicular cancer in the United States and Europe between 1992 and 2009 / World J Urol 33:623~631
Germà-Lluch JR / 2002 / Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish Germ-Cell Cancer Group (GG) / Eur Urol 42:553~562
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