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자료유형
학술저널
저자정보
장민철 (영남대학교) 황종문 (경북대학교병원) 전재한 (경북대학교) 곽상규 (대구가톨릭대학교) 박동휘 (울산대학교) 문준성 (영남대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.3
발행연도
2020.1
수록면
595 - 601 (7page)

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Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, which prompts a consensus for the necessityto seek risk factors for this critical disease. Risk factors affecting mortality of the disease remain elusive. Diabetes and hyperglycemia are known to negatively affect a host’s antiviral immunity. We evaluated the relationship between a history of diabetes, fastingplasma glucose (FPG) levels and mortality among severely ill patients with COVID-19. Methods: This was a retrospective cohort study that assessed 106 adult inpatients (aged ≥18 years) from two tertiary hospitals inDaegu, South Korea. The participants were transferred to tertiary hospitals because their medical condition required immediate intensive care. The demographic and laboratory data were compared between COVID-19 patients who survived and those who didnot. Results: Compared with the survivor group, age, and the proportions of diabetes, chronic lung disease and FPG were significantlyhigher in the deceased group. In the Cox proportional hazards regression model for survival analysis, FPG level and age were identified as significant predictors of mortality (P<0.05). The threshold values for predicting high mortality were age >68 years and FPGof 168 mg/dL, respectively. Among those without diabetes, high FPG remained a significant predictor of mortality (P<0.04). Conclusion: High FPG levels significantly predicted mortality in COVID-19, regardless of a known history of diabetes. These results suggest intensive monitoring should be provided to COVID-19 patients who have a high FPG level.

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