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자료유형
학술저널
저자정보
김경수 (차의과학대학교) 박석원 (Department of Internal Medicine Yonsei University College of Medicine) 조용욱 (차의과학대학교) 김수경 (차의과학대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.35 No.1
발행연도
2020.1
수록면
97 - 105 (9page)

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Background: To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) at mid-pregnancy and postpartum glucose intolerance in women with gestational diabetes mellitus (GDM). Methods: We enrolled 348 pregnant women diagnosed with GDM from August 2012 to October 2016. We measured serum 25(OH)D levels at mid-pregnancy and carried out a 75-g oral glucose tolerance test at 6 to 12 weeks after delivery. Vitamin D deficiencywas defined as serum 25(OH)D <20 ng/mL. Results: The prevalence of vitamin D deficiency was 76.7% (n=267). Women with vitamin D deficiency had a higher prevalence ofpostpartum glucose intolerance than did those without vitamin D deficiency (48.7% vs. 32.1%, P=0.011). Serum 25(OH)D levelwas negatively correlated with hemoglobin A1c at antepartum and postpartum period (antepartum: r=–0.186, P=0.001; postpartum:r=–0.129, P=0.047). Homeostasis model assessment of β-cell function was positively correlated with serum 25(OH)D level onlypostpartum (r=0.138, P=0.035). The risk of postpartum glucose intolerance was 2.00 times (95% confidence interval, 1.13 to 3.55)higher in women with vitamin D deficiency than in those without vitamin D deficiency (P=0.018). Conclusion: In women with GDM, vitamin D deficiency at mid-pregnancy is associated with an elevated risk of postpartum glucoseintolerance.

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