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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 471 - 480 (10page)
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초록· 키워드
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Due to their ability to be internalized into cells by endocytosis through cell membranes, the application of nanoparticlesin therapeutic and diagnostic fields has received much interest. In particular, ferrite magnetic nanoparticles (MNPs) arewidely used as reagents for medical care, including in vitro magnetic separation, T2-weighted magnetic resonance imaging,magnetic hyperthermia therapy, and as drug delivery systems. However, little is known about the quantitative analysis ofthe cellular uptake of MNPs by the interaction of particle surfaces with biomolecules. Here, we quantitatively analyze theintracellular uptakes of 30 nm Fe- and Mn-ferrite MNPs. We confirm that the magnetic properties of MNPs change accordingto their microstructure and quantitatively analyze nanoparticle internalization in breast cell lines (MCF10A, MCF7, andMDA-MB-231) by measuring the magnetic moment using a vibrating sample magnetometer. Finally, we examine the effectof nanoparticle microstructure on cellular uptake in terms of the interaction between the nanoparticles and biomolecules.
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참고문헌 (40)
참고문헌 신청
Liong, M. / 2008 / Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery / ACS Nano 2:889
Park, S. / 2017 / Towards clinically translatable in vivo nanodiagnostics / Nat. Rev. Mater 2:17014
Park, B. C. / 2017 / Photonic reactions leading to fluorescence in a polymeric system induced by the photothermal effect of magnetite nanoparticles using a 780-nm multiphoton laser / Small 13:1700897
Yoon, H. Y. / 2013 / Synthesis, microstructure, and magnetic properties of monosized MnxZnyFe3−x−yO4 ferrite nanocrystals / Nanoscale Res. Lett 8:530
Choi, Y.S. / 2014 / Synthesis and magnetic properties of size-tunable MnxFe3−xO4 ferrite nanoclusters / J. Appl. Phys 115:17B517
Park, S. / 2017 / Towards clinically translatable in vivo nanodiagnostics / Nat. Rev. Mater 2:17014
Park, B. C. / 2017 / Photonic reactions leading to fluorescence in a polymeric system induced by the photothermal effect of magnetite nanoparticles using a 780-nm multiphoton laser / Small 13:1700897
Yoon, H. Y. / 2013 / Synthesis, microstructure, and magnetic properties of monosized MnxZnyFe3−x−yO4 ferrite nanocrystals / Nanoscale Res. Lett 8:530
Choi, Y.S. / 2014 / Synthesis and magnetic properties of size-tunable MnxFe3−xO4 ferrite nanoclusters / J. Appl. Phys 115:17B517
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