지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 36 - 41 (6page)
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초록· 키워드
오류제보하기
Objective: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration. Methods: Intervertebral disc tissue was separated into annulus fibrosus/nucleus pulposus and cultured separately in vitro in serum-free medium (Opti-MEM). Conditioned media was collected after 48 hours. The concentration of IL-6 was quantified using enzyme-linked immunosorbent assay. Pearson correlation coefficients quantified relationships between IL-6 levels and pre- and postoperative visual analogue scale (VAS) back pain and Oswestry Disability Index (ODI), as well as change in VAS/ODI. Results: Sixteen discs were harvested from 9 patients undergoing anterior lumbar interbody fusion (mean age, 47.4 years; range, 21–70 years). Mean preoperative and 6-month postoperative VAS were 8.1 and 3.7, respectively. Mean preoperative and postoperative ODI were 56.2 and 25.6, respectively. There were significant positive correlations between IL-6 expression and postoperative VAS (ρ=0.38, p=0.048) and ODI (ρ=0.44, p=0.02). No significant correlations were found between intradiscal IL-6 expression and preoperative VAS (ρ=-0.12, p=0.54). Trends were seen associating IL-6 expression and change in VAS/ODI (ρ=-0.35 p=0.067; ρ=-0.34, p=0.08, respectively). A trend associated IL-6 and preoperative ODI (ρ=0.36, p=0.063). Conclusion: The direct association between IL-6 expression and VAS/ODI suggests patients with elevated intradiscal cytokine expression may have worse early outcomes than those with lower expression of IL-6 after surgery for symptomatic disc degeneration.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Kuslich SD / 1991 / The tissue origin of low back pain and sciatica : a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia / Orthop Clin North Am 22:181~187
Schwarzer AC / 1994 / The relative contributions of the disc and zygapophyseal joint in chronic low back pain / Spine 19:801~806
United States Bone and Joint Initiative / 2020 / The burden of musculoskeletal diseases in the United States (BMUS) / United States Bone and Joint Initiative
Boden SD / 1990 / Abnormal magneticresonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation / J Bone Joint Surg Am 72:403~408
Manchikanti L / 2018 / An update of the systematic appraisal of the accuracy and utility of discography in chronic spinal pain / Pain Physician 21:91~110
Schwarzer AC / 1994 / The relative contributions of the disc and zygapophyseal joint in chronic low back pain / Spine 19:801~806
United States Bone and Joint Initiative / 2020 / The burden of musculoskeletal diseases in the United States (BMUS) / United States Bone and Joint Initiative
Boden SD / 1990 / Abnormal magneticresonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation / J Bone Joint Surg Am 72:403~408
Manchikanti L / 2018 / An update of the systematic appraisal of the accuracy and utility of discography in chronic spinal pain / Pain Physician 21:91~110
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