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논문 기본 정보

자료유형
학술저널
저자정보
Park Jin Kyun (Division of Rheumatology Department of Internal Medicine Seoul National University College of Medic) Lee Eun Bong (Division of Rheumatology Department of Internal Medicine Seoul National University College of Medic) Shin Kichul (Division of Rheumatology Seoul Metropolitan Government-Seoul National University Boramae Medical Ce) Sung Yoon-Kyoung (Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul Korea.) Kim Tae Hwan (Department of Rheumatology Hanyang University Hospital for Rheumatic Diseases Seoul Korea.) Kwon Seong-Ryul (Division of Rheumatology Department of Internal Medicine Rheumatism Center Inha University Hospital) Lee Myeung Su (Division of Rheumatology Department of Internal Medicine Wonkwang University Iksan Korea.) Hong Seung-Jae (Division of Rheumatology Department of Internal Medicine Kyung Hee University Hospital Seoul Korea.) Choi Byoong Yong (Department of Internal Medicine Seoul Medical Center Seoul Korea.) Lee Shin-Seok (Department of Rheumatology Chonnam National University Medical School & Hospital Gwangju Korea.) Back Han Joo (Division of Rheumatology Department of Internal Medicine Gachon University College of Medicine Gil)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.12
발행연도
2021.1
수록면
1 - 12 (12page)

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The coronavirus disease 2019 (COVID-19) pandemic has caused more than 100 million infections and 2 million deaths worldwide. In up to 20% of cases, COVID-19 infection can take a severe, life-threatening course. Therefore, preventive measures such as mask-wearing, hand hygiene, and social distancing are important. COVID-19 vaccines that use novel vaccine technology can prevent up to 95% of infections. However, the uncertainty regarding the efficacy and safety of vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), who are immunocompromised due to underlying immune dysfunction and concomitant immunosuppressive treatment, warrants clear guidance. A task force of the Korean College of Rheumatology formulated a set of vaccination guidance based on the currently available data and expert consensus. The currently available COVID-19 vaccines are considered to be safe and effective. Every patient with AIIRD should receive one of the available COVID-19 vaccines unless contraindicated for medical reasons such as prior allergy/anaphylaxis to the COVID-19 vaccine or its components. Patients should continue immunosuppressive treatment for their underlying AIIRD, including biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs). Corticosteroids should be reduced to the lowest dose possible without aggravating the AIIRD. To improve the vaccine response, methotrexate can be withheld for 1–2 weeks after each vaccination, and the timing of rituximab and abatacept infusion should be adjusted if clinically acceptable. Rheumatologists should play a leading role in educating and vaccinating patients with AIIRD.
#COVID-19 #Autoimmune Inflammatory Rheumatic Diseases #Vaccines #Immunosuppression

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참고문헌 (62)

참고문헌 신청
Wu Z / 2020 / Characteristics of and important lessons from the coronavirus disease 2019(COVID-19)outbreak in china : summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention / JAMA 323(13):1239~1242 google schola Zhou F / 2020 / Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China : a retrospective cohort study / Lancet 395(10229):1054~1062 google schola Sette A / 2021 / Adaptive immunity to SARS-CoV-2 and COVID-19 / Cell 184(4):861~880 google schola Kim MJ / 2020 / Profile of common inflammatory markers in treatment-naïve patients with systemic rheumatic diseases / Clin Rheumatol 39(10):2899~2906 google schola Schett G / 2013 / How cytokine networks fuel inflammation : Toward a cytokine-based disease taxonomy / Nat Med 19(7):822~824 google schola

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