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논문 기본 정보

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학술저널
저자정보
Kang Hye-Rin (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Division) Lee Ye Jin (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Kang Dong) Lee Ha Youn (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Serim General Hosp) Park Tae Yun (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul Metropolitan) Lee Jung-Kyu (Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Seoul Metropolitan) Heo Eun Young (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Division) Chung Hee Soon (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Division) Choi Seung Ho (Department of Internal Medicine Healthcare Research Institute Healthcare System Gangnam Center Seou) Kim Deog Kyeom (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Division)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.5
발행연도
2021.1
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1 - 10 (10page)

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Background: The impact of reflux esophagitis on the decline of lung function has been rarely reported. This study was performed to evaluate the association between erosive reflux esophagitis and lung function changes. Methods: We included patients with normal lung function who underwent esophagogastroduodenoscopy for health screening from a health screening center. Patients with persistent erosive reflux esophagitis on two discrete endoscopic examinations were designated as the erosive reflux esophagitis group. We also selected patients without erosive reflux esophagitis and matched them 1:4 with patients from the erosive reflux esophagitis group. We estimated annual forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) changes from baseline and compared these estimates by the linear mixed regression model. We also estimated the biannual incidence of chronic obstructive pulmonary disease (COPD). Results: In total, 1,050 patients (210 patients with erosive reflux esophagitis, and 840 matched controls) were included. The median follow-up duration for spirometry was six years. In patients with erosive reflux esophagitis, mild reflux esophagitis (A grade) was most common (165 patients, 78.6%). The adjusted annual FEV1 change in patients with erosive reflux esophagitis was −51.8 mL/yr, while it decreased by 46.8 mL/yr in controls (P = 0.270). The adjusted annual FVC decline was similar between the two groups (−55.8 vs. −50.5 mL/ yr, P = 0.215). The estimated COPD incidence during the follow-up period was not different between the erosive reflux esophagitis and control groups. Conclusion: In patients with normal lung function, the presence of erosive reflux esophagitis did not affect the annual declines in FEV1 or FVC.
#Gastroesophageal Reflux #Respiratory Function Tests #Forced Expiratory Volume #Vital Capacity #Pulmonary Disease #Chronic Obstructive #Community Health Services

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참고문헌 (29)

참고문헌 신청
Vakil N / 2010 / Disease definition, clinical manifestations, epidemiology and natural history of GERD / Best Pract Res Clin Gastroenterol 24(6):759~764 google schola Gaude GS / 2009 / Pulmonary manifestations of gastroesophageal reflux disease / Ann Thorac Med 4(3):115~123 google schola Field SK / 1999 / A critical review of the studies of the effects of simulated or real gastroesophageal reflux on pulmonary function in asthmatic adults / Chest 115(3):848~856 google schola Iliaz S / 2016 / Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations / Respir Med 115:20~25 google schola Vakil N / 2006 / The Montreal definition and classification of gastroesophageal reflux disease : a global evidence-based consensus / Am J Gastroenterol 101(8):1900~1920 google schola

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