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자료유형
학술저널
저자정보
전영준 (계명대학교) 김진영 (계명대학교) 서영주 (연세대학교) 이지연 (계명대학교) 박재석 (계명대학교) 문성민 (계명대학교) 이무숙 (계명대학교) 이재혁 (계명대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.34
발행연도
2020.1
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1 - 12 (12page)

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Background: The predictors of poor prognosis in patients with coronavirus disease 2019 (COVID-19) using computed tomography (CT) have not been investigated in a large cohort. Therefore, the purpose of this study was to investigate the adverse initial CT features to predict poor prognosis in COVID-19. Methods: From February to April 2020, 281 COVID-19 patients who underwent CT at the time of admission were included. We divided the patients into the severe and non-severe disease groups. The severe group included patients with severe pneumonia or critical events. Intensive care unit admission or death were the critical events in this study. We compared the clinical and CT findings between the severe and non-severe groups and investigated the prognostic factors and critical events of the severe group using the regression analysis. Results: Among the 281 patients, 36 (12.8%) patients were in the severe group and 245 (87.2%) patients were in the non-severe group. Critical events occurred in 10 patients (3.6%). In the severe group, patients showed significantly more pneumonia with consolidation, crazy-paving appearance, pleural effusion, and higher CT scores than those in the non-severe group (all, P < 0.05). In the multivariate regression, pleural effusion (odds ratio [OR], 8.96; 95% confidence interval [CI], 1.81–44.42; P = 0.007), CT score > 5 (OR, 3.70; 95% CI, 1.44– 9.53; P = 0.007), old age (> 77 years, OR, 9.96; 95% CI, 3.78–26.28; P < 0.001), and elevated C-reactive protein (OR, 4.15; 95% CI, 1.62–10.6; P = 0.003) were significant prognostic factors of severe disease. CT score > 5 (OR, 7.29; 95% CI, 1.37–38.68; P = 0.020), pleural effusion (OR, 5.67; 95% CI, 1.04–30.8; P = 0.045) and old age (OR, 8.6; 95% CI, 1.80–41.0; P = 0.007) were also significant predictors of critical events. Conclusion: Pleural effusion and the extent of pneumonia on initial CT scans are associated with poor prognosis in patients with COVID-19.

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