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논문 기본 정보

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저자정보
Eu Suk Kim (Department of Internal Medicine Seoul National University College of Medicine) Bum Sik Chin (National Medical Center) 강창경 (서울대학교 의과대학 내과학교실) Nam Joong Kim (Department of Internal Medicine Seoul National University College of Medicine) Yu Min Kang (Myongji Hospital) Jae-Phil Choi (Seoul Medical Center) Dong Hyun Oh (Seoul Medical Center) Jeong-Han Kim (Armed Forces Capital Hospital) Boram Koh (Gyeonggi Provincial Medical Center Ansung Hospital) Seong Eun Kim (Chonnam National University Medical School) Na Ra Yun (Division of Infectious Disease Department of Internal Medicine Chosun University College of Medicin) Jae Hoon Lee (Department of Internal Medicine Wonkwang University School of Medicine Iksan Korea) Jin Yong Kim (Incheon Medical Center) Yeonjae Kim (국립의료원 내과) Ji Hwan Bang (Seoul Metropolitan Government-Seoul National University Boramae Medical Center) Kyoung-Ho Song (Department of Internal Medicine Seoul National University College of Medicine) Hong Bin Kim (Department of Internal Medicine Seoul National University College of Medicine) Ki-hyun Chung (National Medical Center) 오명돈 (서울대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.13
발행연도
2020.1
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1 - 12 (12page)

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. Methods: All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. Results: The median age was 40 years (range, 20–73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5–7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT). Conclusion: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.
#COVID-19 #SARS-CoV-2 #Viral Pneumonia #Prognosis #Cohort Study #Republic of Korea

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참고문헌 (26)

참고문헌 신청
Zhu N / 2020 / A novel coronavirus from patients with pneumonia in China, 2019 / N Engl J Med 382(8):727~733 google schola World Health Organization main website google schola 최원석 / 2016 / Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea / Infection and Chemotherapy 48(2):118~126 google schola Jin Yong Kim / 2020 / The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures / Journal of Korean Medical Science 35(5):1~4 dbpia Jin Yong Kim / 2020 / Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea / Journal of Korean Medical Science 35(7):1~7 dbpia

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