지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective. Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disorder that impairs patients’ overall health-related quality of life (HRQOL). In this study, we evaluated the effect of adalimumab in Korean patients with active RA on HRQOL. Methods. Patients included in the study had moderate to severe active RA that did not respond to conventional drugs with a Disease Activity Score of 28 joints ＞3.2 and were biologics-naïve. All patients received adalimumab 40 mg subcutaneously every other week and were followed for 24 weeks. The primary endpoint was the change in baseline Health Assessment Questionnaire Disability Index (HAQ-DI) score at week 24. Secondary endpoints were changes in the EuroQol 5-dimension 3-Level (EQ-5D-3L) baseline score and Short Form 36-Item Health Survey (SF-36) domain scores at weeks 12 and 24 and change in baseline HAQ-DI score at week 12. Results. In total, 91 Korean patients were included. Ninety-three percent of patients were in high disease activity with a baseline mean DAS28 value of 6.1 within all patients. The mean change from baseline in HAQ-DI scores were −0.46 at week 12 and∼0.67 at week 24 (p＜0.0001). Additionally, EQ-5D-3L score at weeks 12 and 24 had significantly improved (p＜0.0001) compared to baseline. SF-36 at weeks 12 and 24 had significantly improved (p＜0.0001, p=0.0001) compared to baseline. Conclusion. Treatment with adalimumab resulted in significant improvement in HAQ-DI, EQ-5D-3L, and SF-36 scores at 12 and 24 weeks in Korean RA patient.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Silman AJ / 2002 / Epidemiology and genetics of rheumatoid arthritis / Arthritis Res 4(Suppl 3):S265~S272
Hyrich K / 2006 / Baseline comorbidity levels in biologic and standard DMARD treated patients with rheumatoid arthritis: results from a national patient register / Ann Rheum Dis 65:895~898
Dougados M / 2014 / Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA) / Ann Rheum Dis 73:62~68
Choi IA / 2019 / Mortality, disability, and healthcare expenditure of patients with seropositive rheumatoid arthritis in Korea : a nationwide population-based study / PLoS One 14:e0210471
Uhlig T / 2007 / Quantification of reduced health-related quality of life in patients with rheumatoid arthritis compared to the general population / J Rheumatol 34:1241~1247
Hyrich K / 2006 / Baseline comorbidity levels in biologic and standard DMARD treated patients with rheumatoid arthritis: results from a national patient register / Ann Rheum Dis 65:895~898
Dougados M / 2014 / Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA) / Ann Rheum Dis 73:62~68
Choi IA / 2019 / Mortality, disability, and healthcare expenditure of patients with seropositive rheumatoid arthritis in Korea : a nationwide population-based study / PLoS One 14:e0210471
Uhlig T / 2007 / Quantification of reduced health-related quality of life in patients with rheumatoid arthritis compared to the general population / J Rheumatol 34:1241~1247
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