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논문 기본 정보

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저자정보
Kim Mi-Ae (Department of Pulmonology Allergy and Critical Care Medicine CHA Bundang Medical Center CHA Univers) Lee Yong Won (Division of Allergy and Clinical Immunology Department of Internal Medicine International St. Mary') 김소리 (Division of Respiratory Medicine and Allergy Department of Internal Medicine Research Center for Pu) 김주희 (한림대학교) 민택기 (Department of Pediatrics Soonchunhyang University Seoul Hospital Soonchunhyang University College o) 박해심 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 신미용 (순천향대학교) 예영민 (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) 이수영 (아주대학교) 이종민 (Department of Pediatrics Yonsei Wonju College of Medicine Wonju Korea.) Choi Jeong Hee (Department of Pulmonology and Allergy Hallym University Dongtan Sacred Heart Hospital Hwaseong and) 장광천 (Department of Pediatrics National Health Insurance Service Ilsan Hospital Ilsan Korea.) 장윤석 (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.4
발행연도
2021.1
수록면
526 - 544 (19page)

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초록· 키워드

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In the era of novel coronavirus epidemics, vaccines against coronavirus disease 2019 (COVID-19) have been recognized as the most effective public health interventions to control the pandemic. An adverse event following immunization (AEFI) is defined as any untoward occurrence following immunization, and the majority of AEFIs are caused by protective immune responses stimulated by vaccines. Most of the reported AEFIs are not serious, and many are not immunologically mediated or even reproducible on re-exposure. However, uncommon severe allergic adverse reactions, such as anaphylaxis or other allergic reactions, can occur after vaccinations. Confirmed allergic reactions to vaccines may be caused by residual non-human protein, preservatives, or stabilizers in the vaccine formulation (also known as excipients). There are 2 main potential allergenic/immunogenic excipients in COVID-19 vaccines, polyethylene glycol (PEG) and polysorbate 80. PEG, also known as macrogol, is an ingredient in various laxatives and injectable formulations, such as depot steroids. Polysorbate 80 is present in various medical products, creams, ointments, lotions, and medication tablets. Contraindications to the administration of COVID-19 vaccines include a previous history of severe allergic reactions to the first dose of COVID-19 vaccine or proven hypersensitivity to a vaccine component, such as PEG or polysorbate 80. Anaphylaxis or other allergic reactions following immunization can cause fear and loss of confidence in the safety of vaccines among the public. A better understanding of these events is thought to help alleviate concerns about the current COVID-19 vaccines and provide reassurance to the general population by analyzing the exact incidence of anaphylaxis and potential risk factors. COVID-19 vaccine-associated anaphylaxis could be prevented and managed by risk stratification based on our local and global experience.
#COVID-19 #vaccine #anaphylaxis #pandemics #public health #immunization #immunity #hypersensitivity #preservatives

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참고문헌 (8)

참고문헌 신청
조영심 / 2009 / 혼합 비타민 주사에 의해 발생한 아나필락시스 1예 / 천식 및 알레르기 29(3):204~207 dbpia Kyungmin Huh / 2021 / Estimating Baseline Incidence of Conditions Potentially Associated with Vaccine Adverse Events: a Call for Surveillance System Using the Korean National Health Insurance Claims Data / Journal of Korean Medical Science 36(9):1~10 dbpia Bae Seongman / 2021 / Adverse Reactions Following the First Dose of ChAdOx1 nCoV-19 Vaccine and BNT162b2 Vaccine for Healthcare Workers in South Korea / Journal of Korean Medical Science 36(17):1~9 dbpia Kim Si-Ho / 2021 / Adverse Events in Healthcare Workers after the First Dose of ChAdOx1 nCoV-19 or BNT162b2 mRNA COVID-19 Vaccination: a Single Center Experience / Journal of Korean Medical Science 36(14):1~8 dbpia Jeon Minji / 2021 / Adverse Events Following Immunization Associated with Coronavirus Disease 2019 Vaccination Reported in the Mobile Vaccine Adverse Events Reporting System / Journal of Korean Medical Science 36(17):1~8 dbpia

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