지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.3
- 발행연도
- 2020.1
- 수록면
- 496 - 506 (11page)
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Purpose: Anaphylaxis is an immediate allergic reaction characterized by potentially life-threatening, severe, systemic manifestations. While studies have evaluated links between serious illness and posttraumatic stress disorder (PTSD), few have investigated PTSD after anaphylaxis in adults. We sought to investigate the psychosocial burden of recent anaphylaxis in Korean adults. Methods: A total of 203 (mean age of 44 years, 120 females) patients with anaphylaxis were recruited from 15 university hospitals in Korea. Questionnaires, including the Impact of Event Scale-Revised-Korean version (IES-R-K), the Korean version of the Beck Anxiety Inventory (K-BAI), and the Korean version of the Beck Depression Inventory (K-BDI), were administered. Demographic characteristics, causes and clinical features of anaphylaxis, and serum inflammatory markers, including tryptase, platelet-activating factor, interleukin-6, tumor necrosis factor-α, and C-reactive protein, were evaluated. Results: PTSD (IES-R-K ≥ 25) was noted in 84 (41.4%) patients with anaphylaxis. Of them, 56.0% had severe PTSD (IES-R-K ≥ 40). Additionally, 23.2% and 28.1% of the patients had anxiety (K-BAI ≥ 22) and depression (K-BDI ≥ 17), respectively. IES-R-K was significantly correlated with both K-BAI (r = 0.609, P < 0.0001) and K-BDI (r = 0.550, P < 0.0001). Among the inflammatory mediators, tryptase levels were lower in patients exhibiting PTSD; meanwhile, platelet-activating factor levels were lower in patients exhibiting anxiety and depression while recovering from anaphylaxis. In multivariate analysis, K-BAI and K-BDI were identified as major predictive variables of PTSD in patients with anaphylaxis. Conclusions: In patients with anaphylaxis, we found a remarkably high prevalence of PTSD and associated psychological distresses, including anxiety and depression. Physicians ought to be aware of the potential for psychological distress in anaphylactic patients and to consider psychological evaluation.
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참고문헌 (36)
참고문헌 신청
Simons FE / 2015 / 2015 update of the evidence base : World Allergy Organization anaphylaxis guidelines / World Allergy Organ J 8:32
Kemp SF / 2002 / Anaphylaxis : a review of causes and mechanisms / J Allergy Clin Immunol 110:341~348
Wang Y / 2019 / The global incidence and prevalence of anaphylaxis in children in the general population : a systematic review / Allergy 74:1063~1080
Sala-Cunill A / 2015 / Biomarkers of anaphylaxis, beyond tryptase / Curr Opin Allergy Clin Immunol 15:329~336
Kessler RC / 2005 / Lifetime prevalence and age-ofonset distributions of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:593~602
Kemp SF / 2002 / Anaphylaxis : a review of causes and mechanisms / J Allergy Clin Immunol 110:341~348
Wang Y / 2019 / The global incidence and prevalence of anaphylaxis in children in the general population : a systematic review / Allergy 74:1063~1080
Sala-Cunill A / 2015 / Biomarkers of anaphylaxis, beyond tryptase / Curr Opin Allergy Clin Immunol 15:329~336
Kessler RC / 2005 / Lifetime prevalence and age-ofonset distributions of DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:593~602
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