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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 518 - 518 (1page)
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Phleichrome, a pigment produced by a phytopathogenic fungus Cladosporium phlei, is a fungal perylenquinone whose photodynamic activity has been intensively studied and can be used in photodynamic therapy for tumor necrosis. Through previous studies, it was confirmed that phleichrome is synthesized through the polyketide synthase pathway, and the polyketide synthase (PKS) gene responsible for the biosynthesis of phleichrome was identified. If phleichrome, a photosensitizer, can be mass-produced using the expression system of Saccharomyces cerevisiae, there will be many advantages for industrial application in tumor treatment. In order to express the PKS gene, activation of PPTase to initiate polyketide synthase pathway is required. However, since ... 전체 초록 보기
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