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논문 기본 정보

자료유형
학술저널
저자정보
Kyeonghee Yoon (Ewha Womans University) Sojung Choi (Ewha Womans University) Hyung-Do Choi (Electronics and Telecommunications Research Institute) Nam Kim (Chungbuk National University) Sang Bong Jeon (Electronics and Telecommunications Research Institute) Kyung-Min Lim (Ewha Womans University) Hae-June Lee (Korea Institute of Radiological & Medical Sciences) Yun-Sil Lee (Ewha Womans University)
저널정보
한국전자파학회JEES Journal of Electromagnetic Engineering And Science Journal of Electromagnetic Engineering And Science Vol.20 No.4
발행연도
2020.10
수록면
307 - 319 (13page)

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초록· 키워드

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The growing concerns regarding the adverse biological effects of radiofrequency electromagnetic fields (RF-EMFs), which are generated by common electronic devices, on the human brain led us to investigate their impact on Alzheimer’s disease (AD). We aimed to establish the effects of RF-EMF on the expression of molecular markers associated with amyloid precursor protein (APP), cell death, and clonogenic survival in HT22 and APP-overexpressing 7w-PSML cells. We compared the effects of RF-EMF at a high specific absorption rate (SAR) level with the neuronal-cell-death-inducing effects of ionizing radiation (IR). RF-EMF exposure (8 W/kg SAR) promoted the protein expression of ADAM10 (α-secretase) in the HT22 cells (p < 0.05) and downregulated the APP mRNA level in the 7w-PSML cells (p < 0.01). In contrast, IR (10 Gy) significantly reduced the APP and a disintegrin and metalloproteinase 10 (ADAM10) levels without altering their respective mRNA levels in these cells. Interestingly, IR exposure significantly upregulated BACE1 (β-secretase) at both the protein and mRNA levels, suggesting adverse effects in AD. IR induced cell death and reduced clonogenic survival in both cell lines. Although RF-EMF (high SAR level) influenced APP processing, it did not induce any deleterious change in either cell line. Thus, further studies are necessary to clarify the influence of RF-EMF on AD.

목차

Abstract
I. INTRODUCTION
II. MATERIALS AND METHODS
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
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