지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 150 - 154 (5page)
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초록· 키워드
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Background and Objectives: Thyroxine is important for brain development. Improper hypothyroid treatment maylead to cognitive and motor impairment, thereby affecting the quality of life. We analyzed the correlation betweenage at first treatment, length of treatment, initial levothyroxine (LT4) dose, and serum levels of free thyroxine(fT4) and thyroid stimulating hormone (TSH) and pediatric quality of life in patients with congenital hypothyroidism(CH). Materials and Methods: This research was a cross-sectional study of 41 children with CH who consumedLT4 for at least 3 months during March 2019-December 2019. The quality of life was assessed from parents’reports using the Pediatric Quality of Life Inventory (PedsQL) generic scale. Spearman correlation analysis wascarried out, and statistical significance was set at p＜0.05. Results: A total of 17 of the 41 children were girls. The mean PedsQL scores in physical and psychosocial functioning were 78.12 (68.75-100) and 233.30(215-251.67), respectively. Age at first treatment was correlated with physical functioning (r=?0.501, p＜0.05)and psychosocial functioning (r=?0.440, p＜0.05). The initial LT4 dose was negatively correlated with physicalfunctioning (r=?0.568, p＜0.05) and psychosocial functioning (r=?0.482, p＜0.05). The length of treatmentshowed a positive correlation with physical functioning (r=0.776, p＜0.05) and psychosocial functioning (r= ?0.852, p＜0.05). However, the serum fT4 and TSH levels were not correlated with quality of life in children withCH (p＞0.05). Conclusion: Age at first treatment, initial dose of LT4, and length of treatment were correlatedwith quality of life in children with CH.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Gaitonde DY / 2012 / Hypothyroidism : an update / Am Fam Physician 86(3):244~251
Counts D / 2009 / Hypothyroidism in children / Pediatr Rev 30(7):251~258
Bhattacharya A / 2013 / Congenital hypothyroidism and developmental difficulties / Gen Med Open Access 1(1):1~4
Rahmani K / 2016 / Congenital hypothyroidism : optimal initial dosage and time of initiation of treatment : a systematic review / Int J Endocrinol Metab 14(3):e36080
Olivieri A / 2015 / Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening / Horm Res Paediatr 83(2):86~93
Counts D / 2009 / Hypothyroidism in children / Pediatr Rev 30(7):251~258
Bhattacharya A / 2013 / Congenital hypothyroidism and developmental difficulties / Gen Med Open Access 1(1):1~4
Rahmani K / 2016 / Congenital hypothyroidism : optimal initial dosage and time of initiation of treatment : a systematic review / Int J Endocrinol Metab 14(3):e36080
Olivieri A / 2015 / Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening / Horm Res Paediatr 83(2):86~93
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