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논문 기본 정보

자료유형
학술저널
저자정보
Karasawa Yuki (Department of Gastroenterology Mitsui Memorial Hospital Tokyo Japan) Kato Jun (Department of Gastroenterology Mitsui Memorial Hospital Tokyo JapanCenter of Endoscopy Mitsui Memo) Kawamura Satoshi (Department of Gastroenterology University of Tokyo Hospital Tokyo Japan) Kojima Kentaro (Department of Gastroenterology Mitsui Memorial Hospital Tokyo Japan) Ohki Takamasa (Department of Gastroenterology Mitsui Memorial Hospital Tokyo Japan) Seki Michiharu (Department of Gastroenterology Mitsui Memorial Hospital Tokyo Japan) Tagawa Kazumi (Department of Gastroenterology Mitsui Memorial Hospital Tokyo Japan) Toda Nobuo (Department of Gastroenterology Mitsui Memorial Hospital Tokyo JapanCenter of Endoscopy Mitsui Memo)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
수록면
616 - 624 (9page)

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Background/Aims: Acute cholangitis (AC) is a potentially life-threatening bacterial infection, and timely antimicrobial treatment, faster than that achieved with bacterial cultures, is recommended. Although the current guidelines refer to empirical antimicrobial treatment, various kinds of antimicrobial agents have been cited because of insufficient analyses on the spectrum of pathogens in AC. Enterococcus spp. is one of the most frequently isolated Gram-positive bacteria from the bile of patients with AC, but its risk factors have not been extensively studied. This study aimed to analyze the risk factors of AC caused by Enterococcus faecalis and Enterococcus faecium. Methods: Patients with AC who were hospitalized in a Japanese tertiary center between 2010 and 2015 were retrospectively analyzed. Patients’ first AC episodes in the hospital were evaluated. Results: A total of 266 patients with AC were identified. E. faecalis and/or E. faecium was isolated in 56 (21%) episodes of AC. Prior endoscopic sphincterotomy (EST), the presence of a biliary stent, prior cholecystectomy, and past intensive care unit admission were more frequently observed in AC patients with E. faecalis and/or E. faecium than in those without such bacteria. Prior EST was identified as an independent risk factor for AC caused by E. faecalis and/or E. faecium in the multivariate analysis. Conclusions: Given the intrinsic resistance of E. faecalis and E. faecium to antibiotics, clinicians should consider empirical therapy with anti-enterococcal antibiotics for patients with prior EST.

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