지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 295 - 306 (12page)
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초록· 키워드
오류제보하기
Background/Aims: Extrahepatic comorbidities and comedication are important to consider in the treatment of chronic hepatitis C (CHC) patients with direct-acting antivirals (DAAs) due to the risk of drug-drug interaction (DDI) and the effect of comorbidities on clinical outcomes. This study aimed to investigate the detailed profiles of comorbidities and comedication among Korean CHC patients. Methods: All adult patients (≥18 years old) with a primary diagnostic code of CHC in 2013 were selected from the National Health Insurance claims database. For each patient, all ICD-10 codes listed as primary or secondary diagnoses and all prescribed medications were collected. Results: Among 47,104 CHC patients (median age, 57 years; male, 49.3%), 84.8% had at least one comorbidity for a mean number of 2.4, which increased with age. The most prevalent comorbidities were hypertension, esophagitis, dyslipidemia, diabetes mellitus, and peptic ulcer. Overall, 96.8% of the patients took at least one prescribed medication, with a mean of 8.1 medications/ year, and the three most common drug types were analgesics, gastrointestinal agents, and antibacterials. Use of at least one drug with a DDI risk category of “contraindicated medication” or “required dose-reduction/additional monitoring” was observed in 97% of the overall patients. The proportion of prescribed medications that were contraindicated with DAAs varied from 2.0% to 38.9% depending on the hepatitis C virus regimen. Conclusions: The majority of CHC patients had comorbidities; almost all patients took multiple prescribed medications, the number of which increased with age, and significant DDI risk was present in 97% of this Korean patient cohort. Comorbidities and comedication profiles should be considered during DAA therapy.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Smolders EJ / 2019 / Cardiovascular risk management and hepatitis C : combining drugs / Clin Pharmacokinet 58:565~592
Smolders EJ / 2017 / The majority of hepatitis C patients treated with direct acting antivirals are at risk for relevant drug-drug interactions / United European Gastroenterol J 5:648~657
Herold C / 2001 / Quantitative testing of liver function in relation to fibrosis in patients with chronic hepatitis B and C / Liver 21:260~265
Frye RF / 2006 / Liver disease selectively modulates cytochrome P450 : mediated metabolism / Clin Pharmacol Ther 80:235~245
Wyffels K / 2019 / Tamoxifen-induced hepatotoxicity caused by drug interaction with direct-acting antiviral agents for hepatitis C / J Oncol Pharm Pract 25:2038~2040
Smolders EJ / 2017 / The majority of hepatitis C patients treated with direct acting antivirals are at risk for relevant drug-drug interactions / United European Gastroenterol J 5:648~657
Herold C / 2001 / Quantitative testing of liver function in relation to fibrosis in patients with chronic hepatitis B and C / Liver 21:260~265
Frye RF / 2006 / Liver disease selectively modulates cytochrome P450 : mediated metabolism / Clin Pharmacol Ther 80:235~245
Wyffels K / 2019 / Tamoxifen-induced hepatotoxicity caused by drug interaction with direct-acting antiviral agents for hepatitis C / J Oncol Pharm Pract 25:2038~2040
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