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논문 기본 정보

자료유형
학술저널
저자정보
Choi Jun-Ho (Department of Internal Medicine Dankook University Hospital Dankook University College of Medicine) Seo Dong-Wan (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K) Song Tae Jun (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K) Park Do Hyun (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K) Lee Sang Soo (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K) Lee Sung Koo (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K) Kim Myung-Hwan (Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul K)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제6호
발행연도
2020.1
수록면
826 - 832 (7page)

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Background/Aims: Interventional endoscopists may utilize contrast-enhanced harmonic endoscopic ultrasound (CEHEUS) for image guidance during radiofrequency ablation (RFA) because of its capability to delineate real-time tumor perfusion dynamics. The purpose of this study was to assess the utility of CEH-EUS for the guidance and monitoring of endoscopic RFA. Methods: Nineteen consecutive patients with solid abdominal tumors who underwent CEH-EUS and endoscopic RFA were included. The extent of the ablation was assessed by CEH-EUS at 5 to 7 days after RFA. Additional RFAs were performed under CEH-EUS guidance. Results: The diagnoses were as follows: nonfunctioning neuroendocrine tumor (n=13), solid pseudopapillary neoplasm (SPN) (n=2), insulinoma (n=1), left adrenal adenoma (n=2), and left adrenal oligometastasis (n=1). Pre-CEH-EUS findings revealed that 17 cases showed hyperenhanced patterns and two cases of SPN showed isoenhanced patterns. CEH-EUS-assisted RFA was technically feasible in all 19 patients. After the first RFA session, seven patients of the treated tumors showed the disappearance of intratumoral enhancement on CEH-EUS, whereas 12 showed residual contrast enhancement. Twelve patients with incomplete ablation were further treated with additional RFA under real-time CEH-EUS guidance. Radiologic complete response was observed in 13 patients (68.4%). Among the 35 ablation procedures, the only adverse events were two episodes of pancreatitis (5.7%; 1 moderate and 1 mild). During the median follow-up of 28 months, the local recurrence rate was 7.7%. Conclusions: The application of CEH-EUS for RFA could be helpful in assessing early treatment response after ablation and targeting residual viable tumors during additional ablation sessions.

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