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논문 기본 정보

자료유형
학술저널
저자정보
Seung Wook Hong (Seoul National University) Jaeyoung Chun (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Jihye Kim (Department of Internal Medicine CHA Gangnam Medical Center CHA University School of Medicine Seoul) Jooyoung Lee (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Hyun Jung Lee (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Hyunsoo Chung (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Soo-Jeong Cho (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Jong Pil Im (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Sang Gyun Kim (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Joo Sung Kim (Department of Internal Medicine and Liver Research Institute Seoul National University College of M)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제14권 제5호
발행연도
2020.1
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589 - 600 (12page)

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Background/Aims: Ghrelin agonists are emerging prokinetic agents for treating gastroparesis. Although recent clinical trials have demonstrated their efficacy in patients with diabetic gastroparesis (DG), the impact of such agents on symptoms and gastric dysmotility remains unclear. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of ghrelin agonists in patients with DG. Methods: A search of common electronic databases (MEDLINE, Embase, and Cochrane Central Register of Controlled Trials) was preformed, using keyword combinations that referenced ghrelin and DG and retrieving all eligible randomized controlled trials (RCTs) of ghrelin agonists versus placebo in patients with DG. The primary outcome measure was the change in patient-reported overall gastroparesis symptom scores. Secondary outcomes included the change in gastric emptying time, specific symptoms related to gastroparesis, and adverse events. A random-effects model was applied to all study outcomes. Heterogeneity among studies was determined by the chi-square test and I2 statistics. Results: We selected six RCTs of patients with DG (n=557) for meta-analysis. Ghrelin agonist administration (vs placebo) significantly improved overall gastroparesis symptoms (standardized mean difference, ?0.34; 95% confidence interval, ?0.56 to ?0.13) and significantly improved symptoms related to gastroparesis, including nausea, vomiting, early satiety, and abdominal pain. Adverse events recorded for ghrelin agonists and placebo did not differ significantly. There was no significant heterogeneity among eligible studies. Conclusions: Compared with placebo, ghrelin agonists are effective and well-tolerated for the treatment of DG.
#Diabetes mellitus #Gastroparesis #Ghrelin #Metaanalysis #Systematic review

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참고문헌 (38)

참고문헌 신청
Camilleri M / 2011 / Epidemiology, mechanisms, and management of diabetic gastroparesis / Clin Gastroenterol Hepatol 9:5~12 google schola Nanlong Liu / 2017 / Gastroparesis Updates on Pathogenesis and Management / Gut and Liver 11(5):579~589 dbpia Choung RS / 2012 / Risk of gastroparesis in subjects with type 1and 2 diabetes in the general population / Am J Gastroenterol 107:82~88 google schola Camilleri M / 2013 / American College of Gastroenterology / Clinical guideline: management of gastroparesis 108:18~37 google schola Kumar M / 2018 / The investigation and treatment of diabetic gastroparesis / Clin Ther 40:850~861 google schola

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