지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 24 - 41 (18page)
이용수
초록· 키워드
오류제보하기
A single layer of squamous endothelial cells (ECs), the endothelium, regulates the flow of substance and fluid into and out of a tissue. The endothelium is also involved in vasculogenesis, the formation of new blood vessels, which is a crucial process for organ development in the embryo and fetus. Because most murine mutations of genes involved in EC development cause early embryo lethality, EC-specific conditional knockout (cKO) mouse models are indispensable for in vivo studies. cKO mice including the floxed allele can be generated through advanced approaches including embryonic stem cell-mediated gene targeting or the CRISPR/Cas system. EC-specific mouse models can be generated through further breeding of floxed mice with a Cre driver line, the latest information of which is available in the Jackson Cre Repository or the EUCOMMTOOLS project. Because it takes a long time (generally 1?2 years) to generate EC-specific mouse models, researchers must thoroughly design and plan a breeding strategy before full-scale mouse experiments, which saves time and money for in vivo study. In summary, revolutionary technical advances in embryo manipulation and assisted reproduction technologies have made it easier to generate EC-specific mouse models, which have been used as essential resources for in vivo studies of the endothelium.
목차
등록된 정보가 없습니다.
참고문헌 (73)
참고문헌 신청
Langille BL / 1981 / Relationship between blood flow direction and endothelial cell orientation at arterial branch sites in rabbits and mice / Circ Res 48:481~488
Eskin SG / 1984 / Response of cultured endothelial cells to steady flow / Microvasc Res 28:87~94
Sontam DM / 2015 / Different exercise modalities have distinct effects on the integrin-linked kinase(ILK)and Ca2+ signaling pathways in the male rat bone / Physiol Rep 3:e12568
Sitia S / 2010 / From endothelial dysfunction to atherosclerosis / Autoimmun Rev 9:830~834
Reriani MK / 2010 / Endothelial function as a functional expression of cardiovascular risk factors / Biomarkers Med 4:351~360
Eskin SG / 1984 / Response of cultured endothelial cells to steady flow / Microvasc Res 28:87~94
Sontam DM / 2015 / Different exercise modalities have distinct effects on the integrin-linked kinase(ILK)and Ca2+ signaling pathways in the male rat bone / Physiol Rep 3:e12568
Sitia S / 2010 / From endothelial dysfunction to atherosclerosis / Autoimmun Rev 9:830~834
Reriani MK / 2010 / Endothelial function as a functional expression of cardiovascular risk factors / Biomarkers Med 4:351~360
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
From breeding mouse to editing mouse genome
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Mice vs. Men
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Modeling human disease in mouse models
한국실험동물학회 학술발표대회 논문집
2020 .07
-
The role of Shank2 in the establishment of cell-intrinsic polarity in cochlear hair cells
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Evaluation of low dose administration of N-methyl-N-nitrosourea to p53 heterozygous knockout mouse
한국실험동물학회 학술발표대회 논문집
2021 .07
-
The mouse one portal(MOP), all Information for all mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Mouse models in cancer research
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Generation of four mouse models for human cancer by engineered nucleases
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Efficient Production of loxP Knock-in Mouse using CRISPR/Cas9 System
대한의생명과학회지
2020 .06
-
Practical production and utilization of genetic modified animals used in new drug development
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Introduction to the center for mouse models of human diseases
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Introduction to the center for mouse models of human diseases
한국실험동물학회 학술발표대회 논문집
2019 .07
-
A Comprehensive Mouse Phenotyping Platform in the Japan Mouse Clinic
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Recent activity of mouse metabolic phenotyping service at Korea Mouse Phenotyping Center (KMPC)
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Production of immunodeficient mouse models to study human diseases
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Evaluation of urethane-induced lung tumor in p53 heterozygous null mice for a short-term carcinogenicity study
한국실험동물학회 학술발표대회 논문집
2021 .01
-
A mouse model with genetic defect of mitochondrial complex I to study neurodegeneration
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Development of OPN over-expression model using cadherin 16-cre mouse for chronic kidney disease
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Systemic infection induced by mouse adenovirus type 1 in FVB-Rag2 knockout mice
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Principles of mouse phenotyping
한국실험동물학회 학술발표대회 논문집
2016 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0