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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제22권 제2호
- 발행연도
- 2021.1
- 수록면
- 85 - 91 (7page)
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초록· 키워드
오류제보하기
Fowl adenovirus serotype-4 (FAdV-4) infection, also known as hydropericardium-hepatitis syndrome (HHS), is one of the most prevalent diseases in the Korean poultry industry. Therefore, an effective vaccination against FAdV-4 should be developed for prevention of HHS infection. However, a standard animal model with significant pathologic characteristics has not been established for evaluation of HHS vaccine efficacy. In this study, we comparatively evaluated FAdV-4 pathogenicity from specific-pathogen-free (SPF) chickens using FAdV-4 strain (ADL091024) isolated in laying chickens in Korea according to chicken age, passage number and virus titers. In brief, FAdV-4 passaged four times in yolk sac of SPF eggs with the highest viral titers could induce the most severe clinical signs in 1-day-old chickens, similar to natural HHS outbreaks. Furthermore, the efficacy of a newly developed attenuated live FAdV-4 vaccine candidate was successfully determined using the established 1-day-old SPF chickens. There was no significant pathogenicity based on the criteria such as mortality, body weight, gross lesions, histological lesions and virus detection rates in the vaccination and non-challenge control groups. However, the challenge group without vaccination showed significant pathogenicity including hepatic necrosis, histological lesion scores in the liver and heart, virus replication and decreased body weight gain. In conclusion, the chicken challenge model established in this report was proposed for consistent and reliable evaluation of FAdV- 4 vaccine efficacy.
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참고문헌 (22)
참고문헌 신청
Choi KS / 2012 / Epidemiological investigation of outbreaks of fowl adenovirus infection in commercial chickens in Korea / Poult Sci 91:2502~2506
Lim TH / 2011 / Identification and virulence characterization of fowl adenoviruses in Korea / Avian Dis 55:554~560
Kim JN / 2008 / Outbreaks of hydropericardium syndrome and molecular characterization of Korean fowl adenoviral isolates / Avian Dis 52:526~530
Ganesh K / 2002 / Detection of fowl adenovirus associated with hydropericardium hepatitis syndrome by a polymerase chain reaction / Vet Res Commun 26:73~80
Hess M / 1999 / Epidemiological studies on fowl adenoviruses isolated from cases of infectious hydropericardium / Avian Pathol 28:433~439
Lim TH / 2011 / Identification and virulence characterization of fowl adenoviruses in Korea / Avian Dis 55:554~560
Kim JN / 2008 / Outbreaks of hydropericardium syndrome and molecular characterization of Korean fowl adenoviral isolates / Avian Dis 52:526~530
Ganesh K / 2002 / Detection of fowl adenovirus associated with hydropericardium hepatitis syndrome by a polymerase chain reaction / Vet Res Commun 26:73~80
Hess M / 1999 / Epidemiological studies on fowl adenoviruses isolated from cases of infectious hydropericardium / Avian Pathol 28:433~439
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