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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 90 - 94 (5page)
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We report a patient with clinical presentation of Lambert-Eaton myasthenic syndrome (LEMS) and paraneoplastic cerebellar degeneration (PCD) prior to the diagnosis of small cell lung cancer (SCLC). A sixty-year-old man suffered from subacute dizziness, ataxia, dysarthria, ptosis, and proximal weakness of limbs. A repetitive nerve stimulation (RNS) test showed a decremental responses at low-frequency (LF) stimulation and an incremental responses at high-frequency (HF) stimulation, suggesting the pattern of LEMS. There was no evidence of a specific lesion on brain magnetic resonance imaging (MRI), so we concluded his cerebellar ataxia, nystagmus and dysarthria were caused by PCD. We suspected that the PCD was coexistent with LEMS as a paraneoplastic neurological syndrome (PNS) associated with SCLC. Initial screening for cancer was negative; however, SCLC was detected through computed tomography of the thorax at four-months follow-up. Early recognition of PNS and repeated screening tests can lead to a timely diagnosis and earlier initiation of treatment of SCLC.
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참고문헌 (8)
참고문헌 신청
Pelosof LC / 2010 / Paraneoplastic syndromes: An approach to diagnosis and treatment / Mayo Clin Proc 85:838~854
Verschuuren JJGM / 2008 / Screening for Small-Cell Lung Cancer: A follow-up study of patients with lambert-eaton myasthenic syndrome / J Clin Oncol 26:4276~4281
Clouston PD / 1992 / Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome / Neurology 42:1944~1950
Clouston PD / 1997 / Small-cell lung cancer, paraneoplastic cerebellar degeneration and the lambert-eaton myasthenic syndrome / Brain 120:1279~1300
Wirtz PW / 2005 / P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer / J Neuroimmunol 164:161~165
Verschuuren JJGM / 2008 / Screening for Small-Cell Lung Cancer: A follow-up study of patients with lambert-eaton myasthenic syndrome / J Clin Oncol 26:4276~4281
Clouston PD / 1992 / Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome / Neurology 42:1944~1950
Clouston PD / 1997 / Small-cell lung cancer, paraneoplastic cerebellar degeneration and the lambert-eaton myasthenic syndrome / Brain 120:1279~1300
Wirtz PW / 2005 / P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer / J Neuroimmunol 164:161~165
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