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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 262 - 273 (12page)
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Purpose: This study aimed to explore the role of the long non-coding RNA (lncRNA) RNA component of mitochondrial RNAase P (RMRP) in sepsis-induced acute kidney injury (AKI). Materials and Methods: Venous blood was collected from septic patients and healthy people. C57BL/6 mice who underwent cecal ligation and puncture (CLP) were used as in vivo models of septic AKI. Lipopolysaccharide (LPS)-induced HK-2 cells were employed as in vitro models of AKI. Flow cytometry analysis was conducted to detect cell apoptosis. Enzyme-linked immunosorbent assay and Western blot assays were used to detect levels of pro-inflammatory cytokines. Results: RMRP was upregulated in sera from patients with AKI and in LPS-induced cells. Knockdown of RMRP inhibited cell apoptosis and reduced production of inflammatory factors in LPS-induced cells, as well as alleviated AKI in CLP mice. RMRP facilitated inflammation by activating NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome. We found that microRNA 206 (miR-206) binds with and is negatively regulated by RMRP: miR-206 directly targets the 3’ untranslated region of DEAD-box helicase 5 (DDX5) and negatively regulates DDX5 expression. By binding with miR-206, RMRP upregulated DDX5 expression. Rescue assays revealed that overexpression of DDX5 counteracted the effect of RMRP inhibition on cell apoptosis and inflammatory response in LPS-induced cells. Conclusion: The lncRNA RMRP contributes to sepsis-induced AKI through upregulation of DDX5 in a miR-206 dependent manner and through activation of NLRP3 inflammasome. This novel discovery may provide a potential strategy for treating AKI.
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참고문헌 (37)
참고문헌 신청
Napolitano LM / 2018 / Sepsis 2018: definitions and guideline changes / Surg Infect(Larchmt) 19:117~125
Zarjou A / 2011 / Sepsis and acute kidney injury / J Am Soc Nephrol 22:999~1006
Prowle JR / 2018 / Sepsis-associated AKI / Clin J Am Soc Nephrol 13:339~342
Uchino S / 2005 / Acute renal failure in critically ill patients : a multinational, multicenter study / JAMA 294:813~818
조강수 / 2018 / Bioactive Compounds for the Treatment of Renal Disease / Yonsei Medical Journal 59(9):1015~1025
Zarjou A / 2011 / Sepsis and acute kidney injury / J Am Soc Nephrol 22:999~1006
Prowle JR / 2018 / Sepsis-associated AKI / Clin J Am Soc Nephrol 13:339~342
Uchino S / 2005 / Acute renal failure in critically ill patients : a multinational, multicenter study / JAMA 294:813~818
조강수 / 2018 / Bioactive Compounds for the Treatment of Renal Disease / Yonsei Medical Journal 59(9):1015~1025
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