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학술저널
저자정보
우아라 (울산대학교) 최하진 (한국보건의료연구원) 신해원 (한국보건의료연구원) 신채민 (한국보건의료연구원) 임채만 (울산대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제12호
발행연도
2020.1
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1,024 - 1,033 (10page)

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Purpose: Patients with respiratory failure associated with neurological dysfunction often require mechanical ventilator support,which poses increased economic burden and ventilator-associated complications. A diaphragm pacing system (DPS) is an implanteddevice that provides respiratory support for such patients. In this systematic review, we reviewed the literature to assessthe safety and efficacy of DPS for patients with respiratory failure resulting from amyotrophic lateral sclerosis (ALS) or cervicalspinal cord injuries. Materials and Methods: The following databases were searched from July 10 to July 30, 2018: MEDLINE, EMBASE, Cochran library,KoreaMed, Research Information Sharing Service, Korean studies Information Service System, Korea Institute of Scienceand Technology Information, and Korean Medical database. The abstracts and full texts of the searched articles were reviewed bytwo reviewers. Results: The search keywords generated 197 articles: two randomized controlled trials, two case-control studies, and one case reportinvolving patients with ALS; one cohort study, one case-control study, and two case reports involving patients with cervicalspine injury; and one case report involving patients with both conditions were included. The primary outcome was safety profile(complications and adverse event) and efficacy (overall survival and sleep improvement). Complications and adverse eventswere more common in patients with ALS and spinal cord injury receiving DPS than in controls. Efficacy outcomes were inconsistentacross ALS studies. Conclusion: Based on safety and efficacy results, we do not support using DPS to manage respiratory failure in patients with ALSor cervical spine injury.

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