지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 72 - 78 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Aging is the most significant risk factor for neurodegenerative disorders that are typified by cognitive deficits. Our recent work utilizing BubR1 hypomorphic (BubR1H/H) mice, an accelerated aging model, has revealed that genetic inhibition of the endogenous Wnt pathway inhibitor secreted frizzled related protein 3 (sFRP3) plays a neuroprotective role. Neuroinflammation has been suggested as a pathological hallmark of age-related neurodegeneration mediating cognitive impairment. However, whether sFRP3 inhibition has a neuroprotective effect on neuroinflammatory gliosis in BubR1H/H mice is unknown. Methods: To investigate neuroprotection from aging-related neuroinflammation by sFRP3 in vivo, we generated double Bub R1H/H;sfrp3 knockout mice and performed immunohistological analysis with cell type-specific markers for astrocytes (glial fibrillary acidic protein), and microglia (ionized calcium-binding adapter molecule 1). Given that the hippocampus is a brain structure critical for learning and memory, and is uniquely affected in aging-related neurodegeneration, we evaluated morphological changes on astrocytes and microglia via confocal imaging. Results: We demonstrate that BubR1H/H mice exhibit significantly increased levels of astrogliosis and an increased trend of microglial activation in the hilus and molecular layer of the young adult hippocampus, thus suggesting that BubR1 insufficiency accelerates glial reactivity. Importantly, our results further show that genetic inhibition of sFRP3 significantly recovers the astrogliosis and microglial activation observed in BubR1H/H mice, suggesting a critical neuroprotective role for sFRP3 in age-related neuroinflammation. Conclusions: Our findings suggest that sFRP3 inhibition may represent a novel therapeutic strategy for neurodegeneration.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice
International Neurourology Journal
2018 .01
-
Single patient classifier as a prognostic biomarker in pT1N1 gastric cancer: results from two large Korean cohorts
대한임상종양학회 학술대회지
2021 .06
-
Sensitive and Noninvasive Detection of Aberrant SFRP2 and MGMT-B Methylation in Iranian Patients with Colon Polyps
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis
PSYCHIATRY INVESTIGATION
2022 .10
-
MGMT-B Gene Promoter Hypermethylation in Patients with Inflammatory Bowel Disease - A Novel Finding
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Is methylation analysis of SFRP2, TFPI2, NDRG4, and BMP3 promoters suitable for colorectal cancer screening in the Korean population?
Intestinal research
2017 .01
-
A mouse model with genetic defect of mitochondrial complex I to study neurodegeneration
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Baicalin protects adults mouse brain against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Field Cancerization in Sporadic Colon Cancer
Gut and Liver
2016 .01
-
LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer
Yonsei Medical Journal
2020 .01
-
Phenotype difference in aged C57BL/6 and 129 mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
The Far-Reaching Effects of Neuroinflammation
International Neurourology Journal
2019 .01
-
Neuroprotection in Schizophrenia and Its Therapeutic Implications
PSYCHIATRY INVESTIGATION
2017 .07
-
Exercise and Neuroinflammation in Health and Disease
International Neurourology Journal
2019 .01
-
Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders
International Neurourology Journal
2016 .01
-
From breeding mouse to editing mouse genome
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Banhasasim-tang reverse memory deficit and neuroinflammation in lipopolysaccharide-induced mice model
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss
Journal of Ginseng Research
2020 .07
-
Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT Profiler PCR Array and immunochemistry assays
Journal of Veterinary Science
2017 .09
-
Phagocytic Roles of Glial Cells in Healthy and Diseased Brains
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0