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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제2호
- 발행연도
- 2021.1
- 수록면
- 179 - 184 (6page)
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Objectives. Resident macrophages are well known to be present in the cochlea, but the exact patterns thereof in spiral ligaments have not been discussed in previous studies. We sought to document the distribution of macrophages in intact cochleae using three-dimensional imaging. Methods. Cochleae were obtained from C-X3-C motif chemokine receptor 1+/GFP mice, and organ clearing was performed. Three-dimensional images of cleared intact cochleae were reconstructed using two-photon microscopy. The locations of individual macrophages were investigated using 100-μm stacked images to reduce bias. Cochlear inflammation was then induced by lipopolysaccharide (LPS) inoculation into the middle ear through the tympanic membrane. Four days after inoculation, three-dimensional images were obtained. Results. Macrophages were scarce in areas adjacent to the stria vascularis, particularly the area just beneath it even though many have suspected macrophages to be abundant in this area. This finding remained consistent upon LPS-induced cochlear inflammation, despite a significant increase in the number of macrophages, compared to non-treated cochlea. Conclusion. Resident macrophages in spiral ligaments are scarce in areas adjacent to the stria vascularis.
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참고문헌 (19)
참고문헌 신청
Wood MB / 2017 / The contribution of immune infiltrates to ototoxicity and cochlear hair cell loss / Front Cell Neurosci 11:106
Hirose K / 2005 / Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma / J Comp Neurol 489(2):180~194
Okano T / 2008 / Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea / J Neurosci Res 86(8):1758~1767
Yang W / 2015 / Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation / Neuroscience 303:1~15
Tornabene SV / 2006 / Immune cell recruitment following acoustic trauma / Hear Res 222(1-2):115~124
Hirose K / 2005 / Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma / J Comp Neurol 489(2):180~194
Okano T / 2008 / Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea / J Neurosci Res 86(8):1758~1767
Yang W / 2015 / Activation of the antigen presentation function of mononuclear phagocyte populations associated with the basilar membrane of the cochlea after acoustic overstimulation / Neuroscience 303:1~15
Tornabene SV / 2006 / Immune cell recruitment following acoustic trauma / Hear Res 222(1-2):115~124
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