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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제14권 제2호
- 발행연도
- 2021.1
- 수록면
- 159 - 168 (10page)
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Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the retrograde flow of gastric contents into the larynx, oropharynx, and/or nasopharynx. It remains controversial whether laryngopharyngeal reflux is a risk factor for laryngeal and hypopharyngeal cancers. The refluxing substances mainly include hydrochloric acid, pepsin, and occasionally bile acids and bile salts, as well as bacteria that colonize the gastrointestinal tract. Loss of epithelium in the mucous membrane of the larynx and hypopharynx is thought to be caused by pepsin. Here, we review the relationships between laryngopharyngeal reflux and both laryngeal and hypopharyngeal carcinomas, as well as the significance of pepsin, methods of clinical detection, and the mechanism of carcinogenesis.
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참고문헌 (121)
참고문헌 신청
Bates JE / 2019 / Locally advanced hypopharyngeal and laryngeal cancer: influence of HPV status / Radiother Oncol 140:6~9
Acuna G / 2019 / Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma / Mod Pathol 32(5):621~626
Du E / 2019 / Long-term survival in head and neck cancer: impact of site, stage, smoking, and human papillomavirus status / Laryngoscope 129(11):2506~2513
Marur S / 2016 / Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment / Mayo Clin Proc 91(3):386~396
Alam MS / 2017 / Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor / J Cancer Res Ther 13(3):430~435
Acuna G / 2019 / Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma / Mod Pathol 32(5):621~626
Du E / 2019 / Long-term survival in head and neck cancer: impact of site, stage, smoking, and human papillomavirus status / Laryngoscope 129(11):2506~2513
Marur S / 2016 / Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment / Mayo Clin Proc 91(3):386~396
Alam MS / 2017 / Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor / J Cancer Res Ther 13(3):430~435
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