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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Recently, a study comprising adult patients with sepsis admitted in the intensive care unit (ICU) was conducted. The patients were treated with high doses of intravenous ascorbic acid, thiamine, and hydrocortisone; the clinical outcomes demonstrated significant therapeutic benefits. The mortality rate in children with sepsis is approximately 25%. However, the effects of additional treatment with ascorbic acid and thiamine (“vitamin protocol”) in children are rarely investigated. Methods: A retrospective analysis was performed using medical records of patients diagnosed with sepsis and admitted to the pediatric ICU (PICU) between September 2016 and June 2019. The control group received treatment only as per sepsis protocol, whereas the treated group received both sepsis protocol and the vitamin protocol. The primary endpoint was change in Vasoactive-Inotropic Score (VIS) for 5 days. The secondary endpoints included the length of stay in the PICU, duration of using mechanical ventilators and vasopressors, and mortality rate. Results: The number of patients in the treated and control groups was 33 and 24, respectively. The treated group showed greater decrease in their VIS for 5 days than the control group (44.4 vs 18.6); however, the difference was not statistically significant. The length of stay in the PICU was significantly longer for the treated group than for the control group [10.0 days (Interquartile range (IQR), 6-18) vs 4.5 days (IQR, 4-10.3); p=0.004]. Conclusions: No significant treatment benefits were observed following vitamin protocol administration to the pediatric patients with sepsis. Further studies are necessary for improving the efficacy and safety of the vitamin protocol.
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참고문헌 (24)
참고문헌 신청
Levy MM / 2018 / The surviving sepsis campaign bundle : 2018 update / Intensive Care Med 44(6):925~928
Weiss SL / 2020 / Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children / Intensive Care Med 46(Suppl 1):10~67
Fleischmann C / 2016 / Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations / Am J Respir Crit Care Med 193(3):259~272
Fleischmann-Struzek C / 2018 / The global burden of paediatric and neonatal sepsis : a systematic review / Lancet Respir Med 6(3):223~230
Tan B / 2019 / Global case-fatality rates in pediatric severe sepsis and septic shock : a systematic review and meta-analysis / JAMA Pediatr 173(4):352~362
Weiss SL / 2020 / Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children / Intensive Care Med 46(Suppl 1):10~67
Fleischmann C / 2016 / Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations / Am J Respir Crit Care Med 193(3):259~272
Fleischmann-Struzek C / 2018 / The global burden of paediatric and neonatal sepsis : a systematic review / Lancet Respir Med 6(3):223~230
Tan B / 2019 / Global case-fatality rates in pediatric severe sepsis and septic shock : a systematic review and meta-analysis / JAMA Pediatr 173(4):352~362
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