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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 18 (18page)
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Background: Olive flounder, Paralichthys olivaceus, is an economically important aquaculture species in Korea. Olive flounders have been heavily damaged by streptococcal infections every year and are treated with antibiotics. However, antibiotic abuse is causing the emergence of resistant strains, and to overcome this, research has shown that new antibiotics must be applied. Tylosin is a relatively safe antibiotic and has good activity against Grampositive bacteria and mycoplasma. We studied the therapeutic effects and side effects of tylosin on Streptococcus parauberis-infected olive flounder. Methods: After artificial infection of olive flounder with S. parauberis SPOF18J3, an appropriate dose of tylosin was confirmed by intramuscular injection (I.M.) at 2.5, 5, 10, and 15 mg/kg, and oral administration at 10 and 20 mg/kg. After I.M. and oral administration dosing of tylosin, side effects were confirmed by serological analysis, histopathological analysis, and median lethal dose (LD50) analysis at both an appropriate concentration and a high concentration. Statistical analysis was performed using one-way analysis of variance (ANOVA) and Tukey’s test (p < 0.05). Results: The appropriate I.M. and oral administration concentration of tylosin administered to olive flounder infected with S. parauberis SPOF18J3 was found to be 10 mg/kg. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were showed not significantly different between the control group and the experimental groups. The histopathologic results showed mild inflammatory responses in muscle and tubular vacuolization and tubular atrophy appeared, but there were no significant differences between the groups. The LD50 was confirmed to be 461mg/kg. Conclusion: In this study, an effective treatment method was provided by verifying the treatment effects and side effects of tylosin in olive flounder infected with S. parauberis, which can be applied directly to aquaculture sites. In addition, these results may be used as a reference for evaluation required upon request to obtain approval for tylosin antibiotics as fishery antibiotics in Korea. After approval, it is possible that a fishery disease manager will be able to prescribe and sell the antibiotic tylosin.
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참고문헌 (30)
참고문헌 신청
Anderson RC / 1966 / The toxicology and pharmacology of tylosin, an antibiotic, and some salts of tylosin
Anderson RC / 1961 / The acute toxicity of tylosin phosphate
Augusto J / 1996 / Gentamicin-induced nephrotoxicity and nephroneogenesis in Oreochromis nilotica, a tilapian fish / Dis. Aquat. Org 26(1):49~58
Baggot JD / 1978 / Some aspects of clinical pharmacokinetics in veterinary medicine:principles of pharmacokinetics / J. Vet. Pharmacol. Ther 1:111~118
Corcoran JW / 1977 / Relationship of ribosomal binding and antibacterial properties of tylosin-type antibiotics / J. Antibiot 30(11):1012~1014
Anderson RC / 1961 / The acute toxicity of tylosin phosphate
Augusto J / 1996 / Gentamicin-induced nephrotoxicity and nephroneogenesis in Oreochromis nilotica, a tilapian fish / Dis. Aquat. Org 26(1):49~58
Baggot JD / 1978 / Some aspects of clinical pharmacokinetics in veterinary medicine:principles of pharmacokinetics / J. Vet. Pharmacol. Ther 1:111~118
Corcoran JW / 1977 / Relationship of ribosomal binding and antibacterial properties of tylosin-type antibiotics / J. Antibiot 30(11):1012~1014
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