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논문 기본 정보

자료유형
학술저널
저자정보
Jung Hyun Park (The Catholic University of Korea) Seung Hee Cho (The Catholic University of Korea) Rip Kim (The Catholic University of Korea) Sang Hoon Na (The Catholic University of Korea) Eun-sun Kang (Incheon St. Mary’s Hospital) Mi-young Yeom (Incheon St. Mary’s Hospital) Yeon Jang (The Catholic University of Korea)
저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제34권 제2호
발행연도
2021.1
수록면
185 - 192 (8page)

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Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of pregabalin (PGB) in a mouse incisional pain model. Methods: A postoperative pain model was induced by hind paw plantar incision in male BALB/c mice. Mice were randomly divided into four groups (n = 8): a salinetreated incision (incision), PGB-treated incision (PGB-incision), sham controls without incision or drug treatment (control), and a PGB-treated control (PGB-control). In the PGB treated groups, PGB was administered intraperitoneally (IP) 30 minutes before and 1 hour after the plantar incision. Changes of the mechanical nociceptive thresholds following incision were investigated. Mice were euthanized for spleen harvesting 12 hours after the plantar incision, and natural killer (NK) cytotoxicity to YAC 1 cells and lymphocyte proliferation responses to phytohemagglutinin were compared among these four groups. Results: Mechanical nociceptive thresholds were decreased after plantar incision and IP PGB administration recovered these decreased mechanical nociceptive thresholds (P < 0.001). NK activity was increased by foot incision, but NK activity in the PGB-incision group was significantly lower than that in the Incision group (P < 0.001). Incisional pain increased splenic lymphocyte proliferation, but PGB did not alter this response. Conclusions: Incisional pain alters cell immunity of the spleen in BALB/c mice. PGB showed antinocieptive effect on mouse incisional pain and attenuates the activation of NK cells in this painful condition. These results suggest that PGB treatment prevents increases in pain induced NK cell activity.
#Analgesics #Immunity #Cellular #Immunomodulation #Killer Cells #Natural #Mice #Pain #Postoperative #Pregabalin #Spleen.

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참고문헌 (27)

참고문헌 신청
Kennedy BC / 1999 / Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? / Acta Anaesthesiol Belg 50:205~209 google schola Kiecolt-Glaser JK / 1998 / Psychological influences on surgical recovery. Perspectives from psychoneuroimmunology / Am Psychol 53:1209~1218 google schola Kehlet H / 2001 / Effect of postoperative analgesia on surgical outcome / Br J Anaesth 87:62~72 google schola Tsai YC / 2000 / Effects of morphine on immune response in rats with sciatic constriction injury / Pain 88:155~160 google schola Beilin B / 2003 / The effects of postoperative pain management on immune response to surgery / Anesth Analg 97:822~827 google schola

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