지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: The purpose of this study is to evaluate the improvement of atopic dermatitis induced by DNCB using pulsed electromagnetic fields (PEMF) stimulation through animal models. Methods: Twenty 6-week Hairless Mouse (SKH1) models were randomly divided into normal groups (n=5), PEMF 15 Hz groups (n=5), PEMF 75 Hz groups (n=5), and Sham groups (n=5). To induce uniform atopic dermatitis, the DNCB(2,4-Dinitrochlorobenzene) solution was applied for 6 weeks. During the process of skin inflammation, sensory evaluations were conducted every 3~4 days to grade symptoms of atopic dermatitis. Following the onset of atopic dermatitis symptoms, the PEMF stimulation (15 mT) in the PEMF group (15 Hz & / 75 Hz) was stimulated for 8 hours per day for 1 week. After all experiments, the dosal skin tissue was sectioned at 4 μm, and after H&E Staining, the skin tissue was observed through the light microscopy to analyze the skin lesion size. Results: As a result of the sensory evaluation, the difference in average sensory evaluation scores between PEMF groups (15 Hz & 75 Hz) was 0.4 points, indicating a low statistical significance. Between the PEMF 15 Hz Group and the Sham Group, the difference in average sensory evaluation scores was reduced to 1.6 points, resulting in high statistical significance (P<0.05) and the best effect. As a result of analyzing the size of the lesion, the difference in size of the lesion area between PEMF groups (15 Hz & 75 Hz) was 807 pixels, indicating a low statistical significance. Between the PEMF group (15 Hz & 75 Hz) and the Sham group, the size difference of the lesion area was 12946 pixels, 13753 pixels, respectively, indicating high statistical significance (P<0.001). It means that inflammation has improved in dorsal skin tissue. Conclusions: This study confirms that PEMF (15 Hz / 75 Hz, 15 mT) stimulation can improve symptoms of DNCB-induced atopic dermatitis.
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참고문헌 (25)
참고문헌 신청
Norlen L / 1998 / A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction / Arch Dermatol Res 290:508~516
Imokawa G / 2009 / A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide / Journal of Dermatological Science 55:1~9
Kang KD / 1992 / A study of peripheral blood eosinophil and serum IgE level in patients with atopic dermatitis / Kor J. Dermatol 30(1):51~56
Oh JW / 2003 / Nationwide study for epidemiological changes of atopic dermatitis in school aged childeren between 1995 and 2000 and kindrgarten aged childeren in 2003 in Korea / Pediatir Allergy Resp 13:277~280
Alibardi L / 2000 / Light and electron microscopical localization of filagrin-like immunoreactivity in normal and regenerating epidermis of the lizard Podarcis muralis / Acta Histochem 102:453~473
Imokawa G / 2009 / A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide / Journal of Dermatological Science 55:1~9
Kang KD / 1992 / A study of peripheral blood eosinophil and serum IgE level in patients with atopic dermatitis / Kor J. Dermatol 30(1):51~56
Oh JW / 2003 / Nationwide study for epidemiological changes of atopic dermatitis in school aged childeren between 1995 and 2000 and kindrgarten aged childeren in 2003 in Korea / Pediatir Allergy Resp 13:277~280
Alibardi L / 2000 / Light and electron microscopical localization of filagrin-like immunoreactivity in normal and regenerating epidermis of the lizard Podarcis muralis / Acta Histochem 102:453~473
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