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논문 기본 정보

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학술저널
저자정보
Shereen M.Samir (Department of Medical Physiology College of Medicine Mansoura University Mansoura 35511 Egypt) Mahmoud Elalfy (Department of Forensic Medicine and Toxicology Faculty of Veterinary Medicine Mansoura University M) Eman Mohamad El Nashar (Department of Anatomy Faculty of Medicine King Khalid University Abha 61421 Saudi ArabiaDepartment) Mansour A.Alghamdi (Department of Anatomy College of Medicine King Khalid University Abha 61421 Saudi ArabiaGenomics an) Eman Hamza (Medical Biochemistry Department College of Medicine Mansoura University Mansoura 35511 Egypt) Mohamed Saad Serria (Medical Biochemistry Department College of Medicine Mansoura University Mansoura 35511 Egypt) Mona G.Elhadidy (Department of Medical Physiology College of Medicine Mansoura University Mansoura 35511 EgyptDepart)
저널정보
대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제4호
발행연도
2021.1
수록면
341 - 354 (14page)

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Cardamonin (CARD) is a chalconoid with anti-inflammatory and antioxidant properties, and it is present in several plants. We sought to explore whether CARD exerts any positive effects against hyperglycemia-induced testicular dysfunction caused by type 2 diabetes and aimed to identify its possible intracellular pathways. Adult male rats were subdivided into six groups: control, CARD, diabetic (DM), DM + glibenclamide (GLIB), DM + CARD and DM + GLIB + CARD. Type 2 DM induced a significant increase in blood glucose and insulin resistance, along with diminished serum insulin, testosterone and gonadotropins levels, which were associated with the impairment of key testicular androgenic enzymes and cellular redox balance. Administration of CARD at a dose of 80 mg/kg for 4 weeks effectively normalized all of these alterations, and the improvement was confirmed by epididymal sperm analysis. After treatment with CARD, the pathological changes in spermatogenic tubules were markedly improved. Significantly, CARD upregulated testicular glucose transporter-8 (GLUT-8) expression and had inhibitory effects on elevated autophagy markers and caspase-3 immunoreactive cells. Furthermore, our results revealed that CARD was able to attenuate damage via activation of Nrf2 through the p62- dependent degradation of testicular anti-Kelch-like ECH-associated protein-1 (Keap- 1). In conclusion, this study suggests that CARD provides protection against diabetic stress-mediated testicular damage. The use of CARD with conventional anti-diabetic therapy was associated with improved efficacy compared with conventional therapy alone.
#Apoptosis #Autophagy #Glucose transporter #Gonadotropins #Insulin sensitivity #Reproductive capacity

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참고문헌 (55)

참고문헌 신청
Olokoba AB / 2012 / Type 2 diabetes mellitus : a review of current trends / Oman Med J 27:269~273 google schola Ciresi A / 2007 / Metabolic parameters and adipokine profile during GH replacement therapy in children with GH deficiency / Eur J Endocrinol 156:353~360 google schola Ding GL / 2015 / The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis / Asian J Androl 17:948~953 google schola Maresch CC / 2018 / Diabetes-induced hyperglycemia impairs male reproductive function : a systematic review / Hum Reprod Update 24:86~105 google schola Kautzky-Willer A / 2016 / Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus / Endocr Rev 37:278~316 google schola

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