지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호
- 발행연도
- 2021.1
- 수록면
- 251 - 258 (8page)
이용수
초록· 키워드
오류제보하기
Flos magnoliae (FM), the dry flower buds of Magnolia officinalis or its related species, is a traditional herbal medicine commonly used in Asia for symptomatic relief of and treating allergic rhinitis, headache, and sinusitis. Although several studies have reported the effects of FM on store-operated calcium entry (SOCE) via the ORAI1 channel, which is essential during intracellular calcium signaling cascade generation for T cell activation and mast cell degranulation, the effects of its isolated constituents on SOCE remain unidentified. Therefore, we investigated which of the five major constituents of 30% ethanoic FM (vanillic acid, tiliroside, eudesmin, magnolin, and fargesin) inhibit SOCE and their physiological effects on immune cells. The conventional whole-cell patch clamp results showed that fargesin, magnolin, and eudesmin significantly inhibited SOCE and thus human primary CD4+ T lymphocyte proliferation, as well as allergen-induced histamine release in mast cells. Among them, fargesin demonstrated the most potent inhibitory effects not only on ORAI1 (IC50 = 12.46 ± 1.300 ?M) but also on T-cell proliferation (by 87.74% ± 1.835%) and mast cell degranulation (by 20.11% ± 5.366%) at 100 ?M. Our findings suggest that fargesin can be a promising candidate for the development of therapeutic drugs to treat allergic diseases.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Junttila IS / 2018 / Tuning the cytokine responses : an update on interleukin(IL)-4 and IL-13 receptor complexes / Front Immunol 9:888
Rajan TV / 2003 / The Gell-Coombs classification of hypersensitivity reactions : a re-interpretation / Trends Immunol 24:376~379
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
Chassin H / 2017 / Sensing and responding to allergic response cytokines through a genetically encoded circuit / Nat Commun 8:1101
Ozdemir C / 2008 / Nature of regulatory T cells in the context of allergic disease / Allergy Asthma Clin Immunol 4:106~110
Rajan TV / 2003 / The Gell-Coombs classification of hypersensitivity reactions : a re-interpretation / Trends Immunol 24:376~379
Galli SJ / 2008 / The development of allergic inflammation / Nature 454:445~454
Chassin H / 2017 / Sensing and responding to allergic response cytokines through a genetically encoded circuit / Nat Commun 8:1101
Ozdemir C / 2008 / Nature of regulatory T cells in the context of allergic disease / Allergy Asthma Clin Immunol 4:106~110
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4+T cells via ORAI1 channel
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes
The Korean Journal of Physiology & Pharmacology
2021 .01
-
학령기 아동의 알레르기 질환 유병률과 관련요인: 국민건강영양조사 자료[2013~2016] 활용
Global Health and Nursing (글로벌 건강과 간호)
2019 .01
-
Anti-allergic effect of Piper nigrum L. extract on allergic asthma and compound 48/80-induced mast cells activation
대한체질인류학회 학술대회 연제 초록
2016 .05
-
노인 알레르기질환의 치료
대한의사협회지
2015 .01
-
알레르기 염증에서의 비만세포 역할과 비만세포 관련 질환
Allergy Asthma & Respiratory Diseases
2017 .01
-
한국 소아 알레르기 역학연구의 과거와 미래
Allergy Asthma & Respiratory Diseases
2018 .09
-
Age-Related Changes in Immunological Factors and Their Relevance in Allergic Disease Development During Childhood
Allergy, Asthma & Immunology Research
2016 .01
-
Anti-inflammatory commensal bacteria and their therapeutic potentials as pharmabiotics in skin allergies
한국실험동물학회 학술발표대회 논문집
2021 .01
-
알레르기질환의 발병에 미치는 인종과 혼합인종 가정의 역할
Allergy Asthma & Respiratory Diseases
2020 .01
-
Genome-wide Association Study of Susceptibility Loci for Self-Reported Atopic Dermatitis and Allergic Rhinitis in the Korean Population
Annals of Dermatology
2024 .04
-
알레르기비염 마우스 모델의 이론과 실제
대한이비인후-두경부외과학회지
2015 .01
-
Anti-allergic effect of a 3,4-dihydroxybenzaldehyde from Polysiphonia morrowii suppress the IgE-mediated allergic response in mast cell and passive cutaneous anaphylaxis animal mouse model
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Effects of Antibiotics on the Development of Asthma and Other Allergic Diseases in Children and Adolescents
Allergy, Asthma & Immunology Research
2018 .01
-
Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII
Allergy, Asthma & Immunology Research
2022 .03
-
한국 소아 알레르기질환의 유전학적 연구 현황과 과제
Allergy Asthma & Respiratory Diseases
2018 .09
-
Phenotypes of allergic diseases in children and their application in clinical situations
Clinical and Experimental Pediatrics
2019 .01
-
한방안이비인후피부과학회지에 게재된 알레르기성 접촉피부염의 실험논문에 대한 고찰
한방안이비인후피부과학회지
2016 .01
-
자주쓴풀 메탄올추출물의 IgE-매개 알레르기 반응 억제 및 기전
생약학회지(Korean Journal of Pharmacognosy)
2020 .12
-
Oleanolic Acid Acetate Inhibits Mast Cell Activation in Ovalbumin-Induced Allergic Airway Inflammation
Allergy, Asthma & Immunology Research
2023 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0