Morin alleviates fructose-induced metabolic syndrome in rats via ameliorating oxidative stress, inflammatory and fibrotic markers

Gehan Hussein Heeba; Esraa Mohamed Rabie; Mekky Mohamed Abuzeid; Amany Abdelrehim Bekhit; Mohamed Montaser Khalifa1

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자료유형: 학술저널

저자정보: Gehan Hussein Heeba (Minia University Egypt) Esraa Mohamed Rabie (Minia University Egypt) Mekky Mohamed Abuzeid (Minia University Egypt) Amany Abdelrehim Bekhit (Minia University Egypt) Mohamed Montaser Khalifa1 (Minia University Egypt)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제3호

발행연도: 2021.1

수록면: 177 - 187 (11page)

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Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type 2 diabetes mellitus. This study aimed to examine the therapeutic effects of morin, as one of the flavonoids constituents, which widely exists in many herbs and fruits, against some metabolic and hepatic manifestations observed in MBS rats and the feasible related mechanisms. MBS was induced in rats by high fructose diet feeding for 12 weeks. Morin (30 mg/ kg) was administered orally to both normal and MBS rats for 4 weeks. Liver tissues were used for determination of liver index, hepatic expression of glucose transporter 2 (GLUT2) as well as both inflammatory and fibrotic markers. The fat/muscle ratio, metabolic parameters, systolic blood pressure, and oxidative stress markers were also determined. Our data confirmed that the administration of morin in fructose diet rats significantly reduced the elevated systolic blood pressure. The altered levels of metabolic parameters such as blood glucose, serum insulin, serum lipid profile, and oxidative stress markers were also reversed approximately to the normal values. In addition, morin treatment decreased liver index, serum liver enzyme activities, and fat/muscle ratio. Furthermore, morin relatively up-regulated GLUT2 expression, however, down-regulated NF-?B, TNF-?, and TGF-? expressions in the hepatic tissues. Here, we revealed that morin has an exquisite effect against metabolic disorders in the experimental model through, at least in part, antioxidant, anti-inflammatory, and anti-fibrotic mechanisms

#Flavonoids #Fructose #Insulin resistance #Liver #Metabolic syndrome

참고문헌 (59)

참고문헌 신청

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