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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제6호
- 발행연도
- 2020.1
- 수록면
- 453 - 462 (10page)
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초록· 키워드
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Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient. Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-carvone against complete Freund’s adjuvant (CFA)-induced arthritis in rats. D-carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthritic rats. Changes in body weight, paw swelling, organ index, hematological parameters, oxidative stress markers, inflammatory cytokines, and histopathology were recorded. Oral treatment of D-carvone significantly improved the body weight, reduced the paw swelling, edema formation, and organ index in arthritic rats. The levels of white blood cells were reduced, red blood cells and hemoglobin levels were improved in D-carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic antioxidants were significantly elevated by D-carvone administration against arthritic rats. D-carvone significantly modulated inflammatory cytokine levels and improved the ankle joint pathology against CFA-induced arthritic inflammation. In conclusion, D-carvone proved significant anti-arthritic activity against CFA-induced arthritis in rats.
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참고문헌 (27)
참고문헌 신청
Poulet B / 2016 / New developments in osteoarthritis and cartilage biology / Curr Opin Pharmacol 28:8~13
Blasioli DJ / 2014 / The roles of catabolic factors in the development of osteoarthritis / Tissue Eng Part B Rev 20:355~363
Wojdasiewicz P / 2014 / The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis / Mediators Inflamm 2014:561459
Wang S / 2016 / Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats / J Ethnopharmacol 187:42~48
Jeong JH / 2015 / Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes / PLoS One 10:e0130882
Blasioli DJ / 2014 / The roles of catabolic factors in the development of osteoarthritis / Tissue Eng Part B Rev 20:355~363
Wojdasiewicz P / 2014 / The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis / Mediators Inflamm 2014:561459
Wang S / 2016 / Anti-inflammatory and anti-arthritic effects of taraxasterol on adjuvant-induced arthritis in rats / J Ethnopharmacol 187:42~48
Jeong JH / 2015 / Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes / PLoS One 10:e0130882
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