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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제5호
- 발행연도
- 2020.1
- 수록면
- 385 - 394 (10page)
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초록· 키워드
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Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatory properties. We report here that eupatilin has a protective effect on the ethanol-induced injury in rats. Sprague?Dawley rats were divided into 6 groups: control, vehicle, silymarin, eupatilin 10 mg/kg, eupatilin 30 mg/kg, and eupatilin 100 mg/kg. Plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed to determine the extent of liver damage. Total cholesterol (TC) and triglycerides (TG) were analyzed to determine the level of liver steatosis. Malondialdehyde level, superoxide dismutase (SOD) activity, and glutathione (GSH) level were analyzed to determine the extent of oxidative stress. Tumor necrosis factor (TNF)-? and interleukin (IL)-1? were quantified to verify the degree of inflammation. Based on our findings, chronic alcohol treatment significantly changed the serum indexes and liver indicators of the model rats, which were significantly improved by eupatilin treatment. Rats in the eupatilin-treatment group showed reduced levels of AST, ALT, TG, TC, TNF-?, and IL-1?, increased SOD activity and GSH levels, and improved overall physiology compared to the alcoholic liver disease model rats. H&E staining also verified the eupatilin-mediated improvement in liver injury. In conclusion, eupatilin inhibits alcohol-induced liver injury via its antioxidant and anti-inflammatory effects.
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참고문헌 (56)
참고문헌 신청
Doody EE / 2017 / Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling / Am J Physiol Gastrointest Liver Physiol 313:G558~G569
Siegmund SV / 2005 / Molecular mechanisms of alcohol-induced hepatic fibrosis / Dig Dis 23:264~274
Goedde HW / 1981 / Alcohol metabolizing enzymes: biochemical properties, genetic heterogeneity and their possible role in alcohol metabolism in humans (author's transl) / J Clin Chem Clin Biochem 19:179~189
Li CJ / 1997 / Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease / Hepatology 26:650~657
Sapkota M / 2014 / Protective role of CYP2E1 inhibitor diallyl disulfide(DADS)on alcohol-induced malondialdehyde-deoxyguanosine(M1dG)adduct formation / Alcohol Clin Exp Res 38:1550~1558
Siegmund SV / 2005 / Molecular mechanisms of alcohol-induced hepatic fibrosis / Dig Dis 23:264~274
Goedde HW / 1981 / Alcohol metabolizing enzymes: biochemical properties, genetic heterogeneity and their possible role in alcohol metabolism in humans (author's transl) / J Clin Chem Clin Biochem 19:179~189
Li CJ / 1997 / Acetaldehyde-modified and 4-hydroxynonenal-modified proteins in the livers of rats with alcoholic liver disease / Hepatology 26:650~657
Sapkota M / 2014 / Protective role of CYP2E1 inhibitor diallyl disulfide(DADS)on alcohol-induced malondialdehyde-deoxyguanosine(M1dG)adduct formation / Alcohol Clin Exp Res 38:1550~1558
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