지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 471 - 479 (9page)
이용수
초록· 키워드
오류제보하기
PurposeHypoxia is widely known as one of the mechanisms of chemoresistance and as an environmental condition which triggers invasion and metastasis of cancer. Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard conjugated with 2-nitroimidazole. Biliary tract cancer (BTC) is known to contain large hypoxic area. This study evaluated the efficacy and safety of evofosfamide as a second-line treatment of advanced BTC. Materials and MethodsPatients received evofosfamide at a dose of 340 mg/m2 on days 1, 8, and 15 of every 28-day cycle. Primary end-point was progression-free survival (PFS) rate at 4-months (4m-PFSR). Secondary end-points included overall survival (OS), PFS, disease control rate (DCR), metabolic response by 18F-fluorodeoxyglucose positron emission tomography (PET), hypoxic parameters evaluated by 18F-fluoromisonidazole (FMISO) PET and toxicity.ResultsTwenty patients were treated with evofosfamide, with 16 response-evaluable patients. There was no objective response; stable disease was observed in nine patients, with a DCR of 56.25%. 4m-PFSR was 40.6%. Median PFS was 3.60 months (95% confidence interval [CI], 1.68 to 5.52). Median OS was 6.37 months (95% CI, 3.94 to 8.79). Reduction of tumor metabolic activity was observed in eight of 15 patients (53.3%). High baseline hypoxic parameters were associated with poor PFS. Change of hypoxic parameters between pretreatment and post-treatment reflected hypoxic-activated drug response. There was no treatment-related death.ConclusionEvofosfamide as second-line treatment of advanced BTC showed acceptable safety and comparable efficacy to other agents. Changes in volumetric parameters measured with FMISO PET, showing the degree of tumor hypoxia, reflected the response to evofosfamide based on the mode of action.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Randi G / 2006 / Gallbladder cancer worldwide : geographical distribution and risk factors / Int J Cancer 118:1591~1602
Marcano-Bonilla L / 2016 / Biliary tract cancers : epidemiology, molecular pathogenesis and genetic risk associations / Chin Clin Oncol 5:61
de Groen PC / 1999 / Biliary tract cancers / N Engl J Med 341:1368~1378
Cereda S / 2013 / Second-line therapy in advanced biliary tract cancer: what should be the standard? / Crit Rev Oncol Hematol 88:368~374
Brieau B / 2015 / Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination : a large multicenter study by the Association des Gastro-Enterologues Oncologues / Cancer 121:3290~3297
Marcano-Bonilla L / 2016 / Biliary tract cancers : epidemiology, molecular pathogenesis and genetic risk associations / Chin Clin Oncol 5:61
de Groen PC / 1999 / Biliary tract cancers / N Engl J Med 341:1368~1378
Cereda S / 2013 / Second-line therapy in advanced biliary tract cancer: what should be the standard? / Crit Rev Oncol Hematol 88:368~374
Brieau B / 2015 / Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination : a large multicenter study by the Association des Gastro-Enterologues Oncologues / Cancer 121:3290~3297
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Synthetic approaches toward [<SUP>18</SUP>F]Fluoromisonidazole as a hypoxia imaging maker
대한방사성의약품학회지
2015 .01
-
[<sup>18</sup>F]Labeled 2-nitroimidazole derivatives for hypoxia imaging
대한방사성의약품학회지
2016 .01
-
Tumor hypoxia and reoxygenation: the yin and yang for radiotherapy
Radiation oncology journal : ROJ
2016 .01
-
Controlled Gene Expression System under Hypoxia Conditions
항공우주의학 학술대회
2015 .05
-
저산소 환경에서의 유전자 발현 조절
항공우주의학회지
2015 .12
-
Gene therapy for neurologic disease using hypoxia-inducible neuron-specific VEGF expression system
항공우주의학 학술대회
2016 .05
-
Hypoxic gene regulation by hypoxia-inducible factor and histone demethylases
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Development of a predictive model for hypoxia due to sedatives in gastrointestinal endoscopy: a prospective clinical study in Korea
Clinical Endoscopy
2024 .07
-
Biodistribution and PET imaging of [<SUP>18</SUP>F]FMISO in mousecolon cancer xenografted mice
대한방사성의약품학회지
2015 .01
-
Hypoxia, Cancer Stem Cells and ID2
대한외과학회 학술대회 초록집
2020 .11
-
[Hepato-Biliary and Pancreas] Impact of Volumetric Parameters on 18F-FDG PET-CT in Pancreatic and Biliary Tract Cancer
대한외과학회 학술대회 초록집
2021 .11
-
Genipin inhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human cervical carcinoma HeLa cells
고신대학교 의과대학 학술지
2019 .01
-
Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells
Journal of Veterinary Science
2021 .07
-
Exposure and Exercise Training in Hypoxic Conditions as a New Obesity Therapeutic Modality: A Mini Review
Journal of Obesity & Metabolic Syndrome
2018 .01
-
Hypoxia Inducible Factor-1α Directly Induces the Expression of Receptor Activator of Nuclear Factor-κB Ligand in MLO-Y4 Osteocytes
International Journal of Oral Biology
2015 .01
-
Direct and Intervertebral DiscMediated Sensitization of Dorsal Root Ganglion Neurons by Hypoxia and Low pH
Neurospine
2020 .01
-
A study of biliary microbiota in patients with biliary tract disease
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Neuroprotective effects of mild hypoxia in organotypic hippocampal slice cultures
Korean journal of pediatrics
2015 .01
-
Hypoxia Increases Epithelial Permeability in Human Nasal Epithelia
Yonsei Medical Journal
2015 .01
-
Distinct prognosis of biliary tract cancer according to tumor location, stage, and treatment: A population-based study
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0