The Broad Variability in Dental Age Observed among Childhood Survivors Is Cancer Specific

Patrycja Proc; Joanna Szczepanska; Malgorzata Zubowska; Beata Zalewska-Szewczyk; Wojciech Mlynarski

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자료유형: 학술저널

저자정보: Patrycja Proc (Medical University of Lodz Poland) Joanna Szczepanska (Medical University of Lodz Poland) Malgorzata Zubowska (Medical University of Lodz Poland) Beata Zalewska-Szewczyk (Medical University of Lodz Poland) Wojciech Mlynarski (Medical University of Lodz Poland)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제1호

발행연도: 2021.1

수록면: 252 - 260 (9page)

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Purpose The study aimed to assess the differences in dental maturation between childhood cancer survivors and healthy children. Materials and Methods Fifty-nine cancer patients including 16 (27.1%) girls and 43 (72.8%) boys, aged between 4 and 16 years, underwent dental and radiographic examinations. The mean duration of anticancer therapy was 16.8 months (range, 1 to 47 months), and 4.6 years (range, 8 to 123 months) had passed since the termination of disease. The control group consisted of 177 panoramic radiographs of age- and sex-matched healthy individuals. Dental age (DA) was estimated with Demirjian’s scale and delta age, i.e., DA?chronological age (CA), was used to compare groups. Results The DA of cancer survivors was accelerated by almost 1 year compared to their CA (9.9±3.1 vs. 8.9±2.8, p=0.040). The greatest difference was observed among patients with brain tumor: delta (DA?CA) was 2.2±1.1 years. Among all cancer patients, only children with familial adenomatous polyposis (FAP)-associated hepatoblastoma (HP) demonstrated delayed DA, with regard to both other cancer survivors (p=0.011) and healthy patients (p=0.037). All four patients with HP suffered from FAP, and three of them had documented adenomatous polyposis coli (APC) genes mutation. The DA of cancer patients having teeth with short roots was significantly greater than that of the cancer survivors without this anomaly (12.8±3.2 vs. 9.0±2.4, p < 0.001). Conclusion DA in children may be altered by cancer disease.

#Cancer survivors #Dental age estimation #Hepatoblastoma #APC genes

참고문헌 (28)

참고문헌 신청

Zubowska M / 2013 / Interleukin 18 as a marker of chronic nephropathy in children after anticancer treatment / Dis Markers 35:811~818

강정민 / 2018 / Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors / Cancer Research and Treatment 50(3):926~935

Patrycja Proc / 2016 / Dental Anomalies as Late Adverse Effect among Young Children Treated for Cancer / Cancer Research and Treatment 48(2):658~667

Kawakami T / 2015 / Cyclophosphamideinduced morphological changes in dental root development of ICR mice / PLoS One 10:e0133256

Kaste SC / 2009 / Impact of radiation and chemotherapy on risk of dental abnormalities : a report from the Childhood Cancer Survivor Study / Cancer 115:5817~5827

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