Adherence to Cancer Prevention Guidelines and Endometrial Cancer Risk: Evidence from a Systematic Review and Dose-Response Meta-analysis of Prospective Studies

Hui Sun; Qing Chang; Ya-Shu Liu; Yu-Ting Jiang; Ting-Ting Gong; Xiao-Xin Ma; Yu-Hong Zhao; Qi-Jun Wu

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자료유형: 학술저널

저자정보: Hui Sun (Shengjing Hospital of China Medical University Shenyang China) Qing Chang (Shengjing Hospital of China Medical University Shenyang China) Ya-Shu Liu (Shengjing Hospital of China Medical University Shenyang China) Yu-Ting Jiang (Shengjing Hospital of China Medical University Shenyang China) Ting-Ting Gong (Shengjing Hospital of China Medical University Shenyang China) Xiao-Xin Ma (Shengjing Hospital of China Medical University Shenyang China) Yu-Hong Zhao (Shengjing Hospital of China Medical University Shenyang China) Qi-Jun Wu (Shengjing Hospital of China Medical University Shenyang China)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제1호

발행연도: 2021.1

수록면: 223 - 232 (10page)

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Purpose The evidence of adherence to cancer prevention guidelines and endometrial cancer (EC) risk has been limited and controversial. This study summarizes and quantifies the relationship between adherence to cancer prevention guidelines and EC risk. Materials and Methods The online databases PubMed, Web of Science, and EMBASE were searched for relevant publications up to June 2, 2020. This study had been registered at PROSPERO. The registration number is CRD42020149966. Study quality evaluation was performed based on the Newcastle-Ottawa Scale. The I2 statistic was used to estimate heterogeneity among studies. Egger’s and Begg’s tests assessed potential publication bias. Summary hazard ratios (HRs) and 95% confi dence intervals (CIs) for the relationship between adherence to cancer prevention guidelines score was assigned to participants by summarizing individual scores for each lifestyle-related factor. The scores ranged from least healthy (0) to most healthy (20) and the EC risk was calculated using a random-effects model. Results Five prospective studies (four cohort studies and one case?cohort study) consisted of 4,470 EC cases, where 597,047 participants were included. Four studies had a low bias risk and one study had a high bias risk. Summary EC HR for the highest vs. lowest score of adherence to cancer prevention guidelines was 0.54 (95% CI, 0.40 to 0.73) and had a high heterogeneity (I2=86.1%). For the dose-response analysis, an increment of 1 significantly reduced the risk of EC by 6%. No signifi cant publication bias was detected. Conclusion This study suggested that adherence to cancer prevention guidelines was negatively related to EC risk.

#Cancer prevention guidelines #Endometrial neoplasms #Risk #Prospective study #Systematic review

참고문헌 (30)

참고문헌 신청

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Sorosky JI / 2012 / Endometrial cancer / Obstet Gynecol 120:383~397

Constantine GD / 2019 / Increased incidence of endometrial cancer following the Women’s Health Initiative : an assessment of risk factors / J Womens Health(Larchmt) 28:237~243

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