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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,229 - 1,241 (13page)
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Purpose This study aimed to present a single institutional experience with BRCA1/2 gene tests and the effects of pathogenic mutations in epithelial peritoneal, ovarian, and fallopian tube cancer (POFTC) on survival outcomes. Materials and Methods We identified patients with epithelial POFTCs who underwent BRCA1/2 gene testing by either germline or somatic methods between March 2007 and March 2020. Based on the BRCA1/2 test results, patients were divided into BRCA mutation and wild-type groups, followed by comparisons of clinicopathologic characteristics and survival outcomes after primary treatment. Results The annual number of POFTC patients who received BRCA1/2 gene tests increased gradually. In total, 511 patients were included and BRCA1/2 mutations were observed in 143 (28.0%). Among 57 patients who received both germline and somatic tests, three (5.3%) showed discordant results from the two tests. Overall, no differences in progression-free survival (PFS; p=0.467) and overall survival (p=0.641) were observed between the BRCA mutation and wild-type groups; however, multivariate analyses identified BRCA1/2 mutation as an independent favorable prognostic factor for PFS (adjusted hazard ratio [aHR], 0.765; 95% confidence interval [CI], 0.593 to 0.987; p=0.040). In 389 patients with International Federation of Gynecology and Obstetrics stage III-IV, different results were shown depending on primary treatment strategy: while BRCA1/2 mutation significantly improved PFS in the subgroup of neoadjuvant chemotherapy (aHR, 0.619; 95% CI, 0.385 to 0.995; p=0.048), it did not affect patient PFS in the subgroup of primary debulking surgery (aHR, 0.759; 95% CI, 0.530 to 1.089; p=0.135). Conclusion BRCA1/2 mutations are frequently observed in patients with epithelial POFTCs, and such patients showed better PFS than did those harboring wild-type BRCA1/2.
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참고문헌 (35)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Kurman RJ / 2010 / The origin and pathogenesis of epithelial ovarian cancer : a proposed unifying theory / Am J Surg Pathol 34:433~443
Levine DA / 2003 / Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations / J Clin Oncol 21:4222~4227
Norquist BM / 2016 / Inherited mutations in women with ovarian carcinoma / JAMA Oncol 2:482~490
Mavaddat N / 2013 / Cancer risks for BRCA1 and BRCA2 mutation carriers : results from prospective analysis of EMBRACE / J Natl Cancer Inst 105:812~822
Kurman RJ / 2010 / The origin and pathogenesis of epithelial ovarian cancer : a proposed unifying theory / Am J Surg Pathol 34:433~443
Levine DA / 2003 / Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations / J Clin Oncol 21:4222~4227
Norquist BM / 2016 / Inherited mutations in women with ovarian carcinoma / JAMA Oncol 2:482~490
Mavaddat N / 2013 / Cancer risks for BRCA1 and BRCA2 mutation carriers : results from prospective analysis of EMBRACE / J Natl Cancer Inst 105:812~822
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