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논문 기본 정보

자료유형
학술저널
저자정보
Massimo Porrini (University of Milan) Umberto Garagiola (University of Milan) Margherita Rossi (University of Milan) Moreno Bosotti (University of Milan) Sonia Marino (University of Milan) Aldo Bruno Gianni (University of Milan) Letterio Runza (University of Milan) Francesco Spadari (University of Milan)
저널정보
대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제42권 제10호
발행연도
2020.1
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1 - 6 (6page)

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Background: Miescher’s cheilitis granulomatosa (MCG) is a rare chronic inflammatory disease and is known as the monosymptomatic clinical form of Melkersson-Rosenthal syndrome (MRS). It is characterised by swelling of one or both lips and more frequently affects the upper lip. Histopathological findings show the presence of numerous inflammatory infiltrates and granuloma formations. Pharmacological treatments and surgery have provided results that are positive yet insufficiently stable in the long term. The clinical case described is of a 68-year-old female patient with a diagnosis of MCG of the upper lip. Case presentation: The patient was diagnosed and treated at the Oral Medicine and Oral Pathology outpatient clinic of Maxillofacial and Odontostomatology Unit, Fondazione Ca Granda IRCCS Ospedale Maggiore Policlinico. The patient was recommended localised treatments of photobiomodulation (PBM) using a diode laser with a 635 nm and 980 nm dual-wavelength (λ) approach, a 600-micron fibre, and a handpiece with a 1-cm-diameter lens at 300 mW. Three treatments a week were administered for four weeks for a total of 12 treatment sessions (T1?T12). After that, the patient had a long follow-up period of about 2 years. The therapeutic results were clear from the initial stages of treatment. There was an immediate, gradual, and consistent reduction in labial swelling. A reduction in the size of the lip by about 35% at T10?T12 was observed, returning the size and volume of the upper lip within the normal clinical range. The painful symptoms subsided after the seventh treatment (T7). The histopathological check at 3 months and the follow-up in particular confirmed the disease was in remission with satisfactorily stable treatment results. Moreover, the patient did not use any other treatments on the area from the early laser treatments through to the end of the follow-up period. Conclusions: Our experience describes a clinical case of MCG treated with PBM and effectively resolved with a reduction of the lip swelling. The real success of the treatment emerged over time, showing that the tissue healing was stable. In absence of any collateral phenomena, this confirms the effective and documented therapeutic potential of PBM for chronic inflammatory infiltrates.
#Diode laser #Photobiomodulation #Miescher granulomatous cheilitis #Orofacial granulomatosis

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참고문헌 (21)

참고문헌 신청
McCartan BE / 2011 / Characteristics of patients with orofacial l granulomatosis / Oral Dis 17:696~704 google schola Jain R / 2020 / Sarcoidosis : Causes, diagnosis, clinical features, and treatments / J Clin Med 9:1081 google schola Terziroli Beretta-Piccoli B / 2018 / Cutaneous granulomatosis : a Comprehensive review / Clin Rev Allergy Immunol 54:131~146 google schola Shah KK / 2017 / Histopathologic review of granulomatous inflammation / J Clin Tuberc Other Mycobact Dis 7:1~12 google schola Troiano G / 2015 / Orofacial granulomatosis : clinical signs of different pathologies / Med Princ Pract 24:117~122 google schola

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