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논문 기본 정보

자료유형
학술저널
저자정보
Song Hyehyun (Department of Psychiatry National Center for Mental Health) Chon Myong-Wuk (Department of Psychiatry National Center for Mental Health) Ryu Vin (Department of Mental Health Research National Center for Mental Health) Yu Rina (Department of Mental Health Research National Center for Mental Health) Lee Dong-Kyun (Department of Mental Health Research National Center for Mental Health) Lee Hyeongrae (Department of Mental Health Research National Center for Mental Health) Lee Wonhye (Department of Clinical Psychology National Center for Mental Health) Lee Jung Hyun (Department of Psychiatry National Center for Mental Health) Park Dong Yeon (Department of Mood Disorders National Center for Mental Health)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제7호
발행연도
2020.1
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627 - 635 (9page)

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Objective More recently, attention has turned to the linkage between childhood trauma and emotional dysregulation, but the evidence in bipolar disorder (BD) is limited. To determine neurobiological relationships between childhood trauma, current anxiety, and impulsivity, we investigated cortical volumetric correlates of these clinical factors in BD.Methods We studied 36 patients with DSM-5 BD and 29 healthy controls. Childhood trauma, coexisting anxiety, and impulsivity were evaluated with the Korean version-Childhood Trauma Questionnaire (CTQ), the Korean version-Beck Anxiety Inventory (BAI), and the Korean version-Barratt Impulsiveness Scale (BIS). Voxel-based morphometry (VBM) was used to assess gray matter volume (GMV) alterations on the brain magnetic resonance imaging (MRI). Partial correlation analyses were conducted to examine associations between the GMV and each scale in the BD group.Results Childhood trauma, anxiety, and impulsivity were interrelated in BD. BD patients revealed significant inverse correlations between the GMV in the right precentral gyrus and CTQ scores (r=-0.609, p<0.0003); between the GMV in the left middle frontal gyrus and BAI scores (r=-0.363, p=0.044). Moreover, patients showed similar tendency of negative correlations between the GMV in the right precentral gyrus and BIS scores; between the GMV in the left middle frontal gyrus and CTQ scores.Conclusion The present study provides evidence for a neural basis between childhood trauma and affect regulations in BD. The GMV alterations in multiple frontal lobe areas may represent neurobiological markers for anticipating the course of BD.

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