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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 100 - 106 (7page)
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초록· 키워드
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Background/Aims: Cholangiocarcinoma (CCA) is a rare but aggressive disease with a poor survival. Recent trials have shownimproved survival with intraductal radiofrequency ablation (RFA) therapy. We performed a systematic review with meta-analysis todetermine the survival benefit of endoscopic RFA for unresectable extrahepatic CCA with malignant biliary obstruction (MBO). Methods: A systematic search from 1970 to 2020 was performed in MEDLINE, EMBASE, Cochrane Library, and ClinicalTrials. gov. We selected eligible studies reporting relative risks, hazard ratios (HRs), or odds ratios, adjusted by controlling for confoundingfactors of survival rate and stent patency duration, among patients with extrahepatic CCA with MBO treated with RFA with stentinsertion or stent insertion only. Results: A total of eight trials (three randomized and five nonrandomized) with a total of 420 patients were included in the metaanalysis. Pooled overall survival analysis favored RFA treatment with stent insertion (HR, 0.47; 95% confidence interval [CI], 0.34?0.64; I2=47%; p=0.09); however, no significant difference was found in the duration of stent patency between the groups (HR, 0.79;95% CI, 0.57?1.09; I2=7%; p=0.36). Conclusions: RFA therapy with stent insertion may confer a survival benefit compared with stent insertion only in patients withCCA and MBO.
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참고문헌 (26)
참고문헌 신청
Vauthey JN / 1994 / Recent advances in the management of cholangiocarcinomas / Semin Liver Dis 14:109~114
Global Burden of Disease Cancer Collaboration / 2015 / The global burden of cancer 2013 / JAMA Oncol 1:505~527
Patel N / 2019 / Incidence of cholangiocarcinoma in the USA from 2001 to 2015: A US cancer statistics analysis of 50 states / Cureus 11:e3962
Zografos GN / 2011 / Cholangiocarcinoma : principles and current trends / Hepatobiliary Pancreat Dis Int 10:10~20
Esnaola NF / 2016 / Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma / Cancer 122:1349~1369
Global Burden of Disease Cancer Collaboration / 2015 / The global burden of cancer 2013 / JAMA Oncol 1:505~527
Patel N / 2019 / Incidence of cholangiocarcinoma in the USA from 2001 to 2015: A US cancer statistics analysis of 50 states / Cureus 11:e3962
Zografos GN / 2011 / Cholangiocarcinoma : principles and current trends / Hepatobiliary Pancreat Dis Int 10:10~20
Esnaola NF / 2016 / Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma / Cancer 122:1349~1369
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