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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제6호
- 발행연도
- 2020.1
- 수록면
- 497 - 503 (7page)
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초록· 키워드
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Background: Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor. In this study, we aim to investigate the value of BAP1 staining of malignant mesothelioma cases with expression loss and diagnosis in cell block and biopsy tissue. Methods: Between January 2009 and March 2017, 64 mesotheliomas, 117 reactive mesothelial hyperplasias, and 20 fibrinous pleuritis/pericarditis were diagnosed with morphologic and immunohistochemical findings in our pathology clinic and were included in the study. Formalin-fixed, paraffin-embedded tissues were immunohistochemically examined for BAP1. Inflammatory and stromal cells were used as positive internal controls. BAP1 was assessed for nuclear staining in mesothelial cells. Results: Examinations of the relationship between patient diagnosis and BAP1 biopsy status showed that the BAP1 loss rate (76.6%) was significantly higher in malignant mesothelioma cases than in other benign diseases (0%) (p < .001). Sensitivity and specificity were 76.56% and 100%, respectively, for biopsy tissue from malignant mesothelioma. Sensitivity and specificity were both 100% for BAP1 test on cell block tissue. Furthermore, the consistency between BAP1 cell block and biopsy results was excellent (ĸ = 0.90) and the correlation was significant (p < .001). Conclusions: This study shows that BAP1 expression loss in both cytology and biopsy tissue in biopsy-confirmed malignant mesothelioma cases is an essential parameter for malignant mesothelioma diagnosis.
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참고문헌 (23)
참고문헌 신청
Cagle PT / 2011 / Pathology of the pleura : what the pulmonologists need to know / Respirology 16:430~438
Carbone M / 2006 / The pathogenesis of mesothelioma / Semin Diagn Pathol 23:56~60
Hicks J / 2006 / Biologic, cytogenetic, and molecular factors in mesothelial proliferations / Ultrastruct Pathol 30:19~30
Hida T / 2017 / Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis : comparison with 9p21 FISH and BAP1 immunohistochemistry / Lung Cancer 104:98~105
Kushitani K / 2018 / Utility of survivin, BAP1, and Ki-67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia / Oncol Lett 15:3540~3547
Carbone M / 2006 / The pathogenesis of mesothelioma / Semin Diagn Pathol 23:56~60
Hicks J / 2006 / Biologic, cytogenetic, and molecular factors in mesothelial proliferations / Ultrastruct Pathol 30:19~30
Hida T / 2017 / Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis : comparison with 9p21 FISH and BAP1 immunohistochemistry / Lung Cancer 104:98~105
Kushitani K / 2018 / Utility of survivin, BAP1, and Ki-67 immunohistochemistry in distinguishing epithelioid mesothelioma from reactive mesothelial hyperplasia / Oncol Lett 15:3540~3547
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